MAP3K5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043507Biological processpositive regulation of JUN kinase activity
GO_0007254Biological processJNK cascade
GO_0070059Biological processintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO_0097190Biological processapoptotic signaling pathway
GO_0002931Biological processresponse to ischemia
GO_0033554Biological processcellular response to stress
GO_0036480Biological processneuron intrinsic apoptotic signaling pathway in response to oxidative stress
GO_0000165Biological processMAPK cascade
GO_0034976Biological processresponse to endoplasmic reticulum stress
GO_0045087Biological processinnate immune response
GO_0046330Biological processpositive regulation of JNK cascade
GO_0045663Biological processpositive regulation of myoblast differentiation
GO_0010666Biological processpositive regulation of cardiac muscle cell apoptotic process
GO_1900745Biological processpositive regulation of p38MAPK cascade
GO_0043280Biological processpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0045860Biological processpositive regulation of protein kinase activity
GO_0072577Biological processendothelial cell apoptotic process
GO_0051403Biological processstress-activated MAPK cascade
GO_0071356Biological processcellular response to tumor necrosis factor
GO_0051402Biological processneuron apoptotic process
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0097300Biological processprogrammed necrotic cell death
GO_0034198Biological processcellular response to amino acid starvation
GO_1902170Biological processcellular response to reactive nitrogen species
GO_0090398Biological processcellular senescence
GO_0006468Biological processprotein phosphorylation
GO_0008631Biological processintrinsic apoptotic signaling pathway in response to oxidative stress
GO_0038066Biological processp38MAPK cascade
GO_0043065Biological processpositive regulation of apoptotic process
GO_1904707Biological processpositive regulation of vascular associated smooth muscle cell proliferation
GO_0070301Biological processcellular response to hydrogen peroxide
GO_1990604Cellular componentIRE1-TRAF2-ASK1 complex
GO_0009897Cellular componentexternal side of plasma membrane
GO_0032991Cellular componentprotein-containing complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_1902911Cellular componentprotein kinase complex
GO_0042803Molecular functionprotein homodimerization activity
GO_0019904Molecular functionprotein domain specific binding
GO_0106310Molecular functionprotein serine kinase activity
GO_0019903Molecular functionprotein phosphatase binding
GO_0019901Molecular functionprotein kinase binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0042802Molecular functionidentical protein binding
GO_0000287Molecular functionmagnesium ion binding
GO_0004672Molecular functionprotein kinase activity
GO_0004709Molecular functionMAP kinase kinase kinase activity
GO_0004706Molecular functionJUN kinase kinase kinase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMAP3K5
Protein namemitogen-activated protein kinase kinase kinase (EC 2.7.11.25)
Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5)
SynonymsMEKK5
MAPKKK5
ASK1
DescriptionFUNCTION: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1). .

AccessionsENST00000359015.5 [Q99683-1]
A0A8V8TMH5
Q99683
ENST00000698928.1