CD207 | OmnibusX

Name	Number of supported studies	Average coverage
Langerhans cell	3 studies	61% ± 28%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of CD207 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	50%	79.98	122 / 245	72%	5.06	359 / 502
uterus	55%	65.19	94 / 170	54%	8.95	250 / 459
skin	72%	1197.82	1298 / 1809	25%	1.84	116 / 472
lung	29%	67.38	169 / 578	57%	13.54	660 / 1155
esophagus	39%	127.40	564 / 1445	44%	5.29	81 / 183
breast	27%	22.73	124 / 459	53%	7.28	596 / 1118
tonsil	0%	0	0 / 0	78%	15.38	35 / 45
thymus	5%	7.02	35 / 653	63%	13.91	384 / 605
pancreas	1%	0.34	2 / 328	62%	6.28	111 / 178
bladder	10%	4.14	2 / 21	32%	5.04	163 / 504
ovary	5%	2.97	9 / 180	34%	3.20	148 / 430
intestine	16%	16.35	151 / 966	18%	0.72	95 / 527
kidney	2%	1.66	2 / 89	31%	2.52	275 / 901
stomach	4%	2.72	13 / 359	19%	0.73	53 / 286
adipose	20%	19.17	235 / 1204	0%	0	0 / 0
spleen	18%	15.33	43 / 241	0%	0	0 / 0
brain	0%	0.07	2 / 2642	17%	0.75	117 / 705
liver	1%	0.45	2 / 226	14%	2.08	57 / 406
adrenal gland	0%	0	0 / 258	12%	0.48	27 / 230
eye	0%	0	0 / 0	5%	0.19	4 / 80
heart	4%	2.96	34 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	3%	0.37	1 / 29
blood vessel	2%	2.25	33 / 1335	0%	0	0 / 0
muscle	0%	0.37	4 / 803	0%	0	0 / 0
peripheral blood	0%	0.10	2 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0051607	Biological process	defense response to virus
GO_0044419	Biological process	biological process involved in interspecies interaction between organisms
GO_0031901	Cellular component	early endosome membrane
GO_0009897	Cellular component	external side of plasma membrane
GO_0030669	Cellular component	clathrin-coated endocytic vesicle membrane
GO_0005886	Cellular component	plasma membrane
GO_0030139	Cellular component	endocytic vesicle
GO_0005537	Molecular function	D-mannose binding
GO_0030246	Molecular function	carbohydrate binding
GO_0005515	Molecular function	protein binding

Gene name	CD207
Protein name	C-type lectin domain family 4 member K (Langerin) (CD antigen CD207)
Synonyms	CLEC4K
Description	FUNCTION: Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation. .
Accessions	ENST00000410009.5 Q9UJ71

CD207 report