STAB2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of STAB2 at tissue level.

III. Associated gene sets

GO_0001525Biological processangiogenesis
GO_0050830Biological processdefense response to Gram-positive bacterium
GO_0007155Biological processcell adhesion
GO_0006897Biological processendocytosis
GO_0030214Biological processhyaluronan catabolic process
GO_0006898Biological processreceptor-mediated endocytosis
GO_0042742Biological processdefense response to bacterium
GO_0030666Cellular componentendocytic vesicle membrane
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0015035Molecular functionprotein-disulfide reductase activity
GO_0005041Molecular functionlow-density lipoprotein particle receptor activity
GO_0030169Molecular functionlow-density lipoprotein particle binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding
GO_0005540Molecular functionhyaluronic acid binding
GO_0005044Molecular functionscavenger receptor activity

IV. Literature review

[source]
Gene nameSTAB2
Protein nameStabilin-2 (FAS1 EGF-like and X-link domain-containing adhesion molecule 2) (Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2) (FEEL-2) (Hyaluronan receptor for endocytosis) [Cleaved into: 190 kDa form stabilin-2 (190 kDa hyaluronan receptor for endocytosis)]
Alternative protein STAB2
Stabilin 2
SynonymsFEX2
FEEL2
HARE
FELL
DescriptionFUNCTION: Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed 190 kDa form also functions as an endocytosis receptor for heparin internalization as well as HA and CS. .

AccessionsH0YHA5
Q8WWQ8
ENST00000549474.1
ENST00000388887.7
H0YIF3
L8E9Z1
ENST00000552777.1