F2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051480Biological processregulation of cytosolic calcium ion concentration
GO_0010544Biological processnegative regulation of platelet activation
GO_0006953Biological processacute-phase response
GO_0030307Biological processpositive regulation of cell growth
GO_0051918Biological processnegative regulation of fibrinolysis
GO_0070945Biological processneutrophil-mediated killing of gram-negative bacterium
GO_1990806Biological processligand-gated ion channel signaling pathway
GO_1900016Biological processnegative regulation of cytokine production involved in inflammatory response
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0007596Biological processblood coagulation
GO_0048712Biological processnegative regulation of astrocyte differentiation
GO_0051838Biological processcytolysis by host of symbiont cells
GO_0042730Biological processfibrinolysis
GO_0032024Biological processpositive regulation of insulin secretion
GO_0030168Biological processplatelet activation
GO_0030193Biological processregulation of blood coagulation
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0045861Biological processnegative regulation of proteolysis
GO_0032967Biological processpositive regulation of collagen biosynthetic process
GO_2000379Biological processpositive regulation of reactive oxygen species metabolic process
GO_0006508Biological processproteolysis
GO_0030194Biological processpositive regulation of blood coagulation
GO_0051281Biological processpositive regulation of release of sequestered calcium ion into cytosol
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0061844Biological processantimicrobial humoral immune response mediated by antimicrobial peptide
GO_0008360Biological processregulation of cell shape
GO_1900738Biological processpositive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway
GO_0009611Biological processresponse to wounding
GO_0046427Biological processpositive regulation of receptor signaling pathway via JAK-STAT
GO_0090218Biological processpositive regulation of lipid kinase activity
GO_1900182Biological processpositive regulation of protein localization to nucleus
GO_0007166Biological processcell surface receptor signaling pathway
GO_0005615Cellular componentextracellular space
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0005796Cellular componentGolgi lumen
GO_0070062Cellular componentextracellular exosome
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0072562Cellular componentblood microparticle
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0008201Molecular functionheparin binding
GO_0070053Molecular functionthrombospondin receptor activity
GO_0005102Molecular functionsignaling receptor binding
GO_0008083Molecular functiongrowth factor activity
GO_0001530Molecular functionlipopolysaccharide binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding
GO_0004252Molecular functionserine-type endopeptidase activity

IV. Literature review

[source]
Gene nameF2
Protein nameProthrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain]
Thrombin factor II
F2 protein
Prothrombin
Plasminogen (EC 3.4.21.7)
Prothrombin (EC 3.4.21.5)
Prothrombin (EC 3.4.21.5) (Coagulation factor II)
Synonyms
DescriptionFUNCTION: Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. .

FUNCTION: Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. .

FUNCTION: Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells. .

AccessionsENST00000311907.10
C9JV37
Q86WA1
Q8TD58
ENST00000442468.1
ENST00000530231.5
A0A2P0ZHX7
Q15253
P00734
E9PIT3