CXCR3 | OmnibusX

Name	Number of supported studies	Average coverage
plasmacytoid dendritic cell	23 studies	51% ± 15%	Explore
CD8-positive, alpha-beta T cell	17 studies	26% ± 8%	Explore
regulatory T cell	9 studies	31% ± 14%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	30% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	23% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	26% ± 6%	Explore
T cell	7 studies	29% ± 10%	Explore
CD4-positive, alpha-beta T cell	6 studies	25% ± 5%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	37% ± 8%	Explore
natural killer cell	5 studies	23% ± 4%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	20% ± 5%	Explore
gamma-delta T cell	5 studies	24% ± 9%	Explore
exhausted T cell	4 studies	47% ± 6%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	32% ± 7%	Explore
mucosal invariant T cell	4 studies	20% ± 4%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	33% ± 4%	Explore
plasmablast	3 studies	39% ± 13%	Explore
mature NK T cell	3 studies	31% ± 6%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of CXCR3 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	93%	86.39	540 / 578	86%	9.50	991 / 1155
stomach	82%	62.41	295 / 359	95%	13.08	271 / 286
thymus	93%	79.12	605 / 653	80%	8.20	481 / 605
intestine	64%	135.69	616 / 966	94%	10.99	497 / 527
prostate	77%	36.89	189 / 245	44%	2.09	219 / 502
uterus	51%	15.90	87 / 170	66%	6.55	302 / 459
esophagus	50%	20.36	719 / 1445	66%	4.78	120 / 183
pancreas	35%	9.24	116 / 328	80%	6.87	142 / 178
breast	38%	12.53	174 / 459	77%	9.11	863 / 1118
kidney	47%	27.55	42 / 89	67%	7.06	607 / 901
bladder	52%	31.86	11 / 21	57%	6.01	287 / 504
lymph node	0%	0	0 / 0	100%	66.38	29 / 29
spleen	100%	561.82	241 / 241	0%	0	0 / 0
peripheral blood	98%	474.50	912 / 929	0%	0	0 / 0
skin	20%	4.93	362 / 1809	72%	14.68	342 / 472
tonsil	0%	0	0 / 0	89%	19.10	40 / 45
ovary	21%	5.58	37 / 180	67%	4.87	289 / 430
adrenal gland	72%	28.56	185 / 258	13%	0.53	31 / 230
liver	42%	10.63	96 / 226	41%	2.88	165 / 406
adipose	60%	22.16	717 / 1204	0%	0	0 / 0
blood vessel	31%	14.75	411 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	30%	3.71	24 / 80
heart	17%	4.63	149 / 861	0%	0	0 / 0
brain	6%	1.36	147 / 2642	7%	0.40	49 / 705
muscle	2%	0.54	20 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0001525	Biological process	angiogenesis
GO_0006954	Biological process	inflammatory response
GO_0019722	Biological process	calcium-mediated signaling
GO_0006935	Biological process	chemotaxis
GO_0007155	Biological process	cell adhesion
GO_0006955	Biological process	immune response
GO_0070098	Biological process	chemokine-mediated signaling pathway
GO_0007204	Biological process	positive regulation of cytosolic calcium ion concentration
GO_0002685	Biological process	regulation of leukocyte migration
GO_0006915	Biological process	apoptotic process
GO_0030155	Biological process	regulation of cell adhesion
GO_0060326	Biological process	cell chemotaxis
GO_0007166	Biological process	cell surface receptor signaling pathway
GO_0009897	Cellular component	external side of plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0009986	Cellular component	cell surface
GO_0005737	Cellular component	cytoplasm
GO_0019956	Molecular function	chemokine binding
GO_0016494	Molecular function	C-X-C chemokine receptor activity
GO_0016493	Molecular function	C-C chemokine receptor activity
GO_0004950	Molecular function	chemokine receptor activity
GO_0019957	Molecular function	C-C chemokine binding
GO_0005515	Molecular function	protein binding

Gene name	CXCR3
Protein name	Chemokine receptor 3 isoform 2 C-X-C chemokine receptor type 3 (CXC-R3) (CXCR-3) (CKR-L2) (G protein-coupled receptor 9) (Interferon-inducible protein 10 receptor) (IP-10 receptor) (CD antigen CD183) C-X-C chemokine receptor type 3 (Interferon-inducible protein 10 receptor) C-X-C chemokine receptor type 3
Synonyms	GPR9
Description	FUNCTION: [Isoform 1]: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway . Binds to CCL21. Probably promotes cell chemotaxis response. .; FUNCTION: [Isoform 2]: Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway . Does not promote cell chemotaxis respons. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis. .; FUNCTION: [Isoform 3]: Mediates the activity of CXCL11.
Accessions	P49682 A0A0S2Z3W9 A0A510GJR7 A0A0S2Z3W5 ENST00000373693.4 [P49682-1] ENST00000373691.4 [P49682-2]

CXCR3 report