EBI3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of EBI3 at tissue level.

III. Associated gene sets

GO_0019221Biological processcytokine-mediated signaling pathway
GO_0032729Biological processpositive regulation of type II interferon production
GO_0042088Biological processT-helper 1 type immune response
GO_0046641Biological processpositive regulation of alpha-beta T cell proliferation
GO_0042098Biological processT cell proliferation
GO_0006959Biological processhumoral immune response
GO_0005615Cellular componentextracellular space
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0009897Cellular componentexternal side of plasma membrane
GO_0043235Cellular componentreceptor complex
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0019955Molecular functioncytokine binding
GO_0045523Molecular functioninterleukin-27 receptor binding
GO_0005515Molecular functionprotein binding
GO_0004896Molecular functioncytokine receptor activity
GO_0005125Molecular functioncytokine activity

IV. Literature review

[source]
Gene nameEBI3
Protein nameInterleukin-27 subunit beta (IL-27 subunit beta) (IL-27B) (Epstein-Barr virus-induced gene 3 protein) (EBV-induced gene 3 protein)
SynonymsIL27B
DescriptionFUNCTION: Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines. .

AccessionsENST00000221847.6
Q14213