Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| type I pneumocyte | 11 studies | 33% ± 9% | |
| club cell | 7 studies | 34% ± 13% | |
| endothelial cell of lymphatic vessel | 7 studies | 28% ± 10% | |
| ionocyte | 4 studies | 78% ± 7% | |
| epithelial cell | 4 studies | 22% ± 5% | |
| basal cell | 4 studies | 23% ± 6% | |
| respiratory goblet cell | 4 studies | 44% ± 19% | |
| renal principal cell | 4 studies | 42% ± 21% | |
| secretory cell | 3 studies | 20% ± 5% |
Insufficient scRNA-seq data for expression of SCNN1B at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 99% | 3080.14 | 572 / 578 | 74% | 33.96 | 855 / 1155 |
| breast | 99% | 2201.29 | 454 / 459 | 62% | 16.55 | 698 / 1118 |
| thymus | 96% | 1210.92 | 629 / 653 | 59% | 7.44 | 356 / 605 |
| bladder | 67% | 853.00 | 14 / 21 | 70% | 57.17 | 353 / 504 |
| prostate | 65% | 1263.83 | 160 / 245 | 43% | 4.01 | 216 / 502 |
| intestine | 70% | 5484.12 | 672 / 966 | 33% | 6.61 | 172 / 527 |
| kidney | 93% | 2314.21 | 83 / 89 | 9% | 3.50 | 78 / 901 |
| uterus | 41% | 547.16 | 69 / 170 | 59% | 29.03 | 273 / 459 |
| ureter | 0% | 0 | 0 / 0 | 100% | 198.17 | 1 / 1 |
| esophagus | 55% | 3301.36 | 799 / 1445 | 40% | 9.96 | 74 / 183 |
| adipose | 93% | 1758.72 | 1125 / 1204 | 0% | 0 | 0 / 0 |
| stomach | 68% | 2088.39 | 244 / 359 | 24% | 3.10 | 69 / 286 |
| tonsil | 0% | 0 | 0 / 0 | 80% | 36.03 | 36 / 45 |
| skin | 72% | 2958.61 | 1305 / 1809 | 8% | 1.16 | 36 / 472 |
| spleen | 47% | 296.82 | 114 / 241 | 0% | 0 | 0 / 0 |
| pancreas | 2% | 12.73 | 7 / 328 | 14% | 4.46 | 25 / 178 |
| blood vessel | 14% | 106.57 | 189 / 1335 | 0% | 0 | 0 / 0 |
| brain | 1% | 3.15 | 17 / 2642 | 10% | 1.64 | 73 / 705 |
| lymph node | 0% | 0 | 0 / 0 | 10% | 0.79 | 3 / 29 |
| ovary | 3% | 14.78 | 5 / 180 | 6% | 1.06 | 26 / 430 |
| muscle | 5% | 32.47 | 38 / 803 | 0% | 0 | 0 / 0 |
| adrenal gland | 1% | 4.20 | 2 / 258 | 3% | 0.91 | 8 / 230 |
| peripheral blood | 2% | 18.45 | 21 / 929 | 0% | 0 | 0 / 0 |
| liver | 0% | 0 | 0 / 226 | 1% | 0.59 | 6 / 406 |
| heart | 0% | 3.68 | 2 / 861 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0003014 | Biological process | renal system process |
| GO_0002269 | Biological process | leukocyte activation involved in inflammatory response |
| GO_0008217 | Biological process | regulation of blood pressure |
| GO_0055078 | Biological process | sodium ion homeostasis |
| GO_0032341 | Biological process | aldosterone metabolic process |
| GO_0035264 | Biological process | multicellular organism growth |
| GO_0050891 | Biological process | multicellular organismal-level water homeostasis |
| GO_0006883 | Biological process | intracellular sodium ion homeostasis |
| GO_0055075 | Biological process | potassium ion homeostasis |
| GO_0050914 | Biological process | sensory perception of salty taste |
| GO_0071468 | Biological process | cellular response to acidic pH |
| GO_0050915 | Biological process | sensory perception of sour taste |
| GO_1904117 | Biological process | cellular response to vasopressin |
| GO_0042045 | Biological process | epithelial fluid transport |
| GO_0034101 | Biological process | erythrocyte homeostasis |
| GO_1904045 | Biological process | cellular response to aldosterone |
| GO_0006814 | Biological process | sodium ion transport |
| GO_0098719 | Biological process | sodium ion import across plasma membrane |
| GO_0014824 | Biological process | artery smooth muscle contraction |
| GO_0070944 | Biological process | neutrophil-mediated killing of bacterium |
| GO_0010467 | Biological process | gene expression |
| GO_0009410 | Biological process | response to xenobiotic stimulus |
| GO_0070254 | Biological process | mucus secretion |
| GO_0032094 | Biological process | response to food |
| GO_0035725 | Biological process | sodium ion transmembrane transport |
| GO_0002283 | Biological process | neutrophil activation involved in immune response |
| GO_0016324 | Cellular component | apical plasma membrane |
| GO_0009897 | Cellular component | external side of plasma membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0034706 | Cellular component | sodium channel complex |
| GO_0030659 | Cellular component | cytoplasmic vesicle membrane |
| GO_0015280 | Molecular function | ligand-gated sodium channel activity |
| GO_0050699 | Molecular function | WW domain binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | SCNN1B |
| Protein name | Epithelial sodium channel beta-3 subunit Amiloride-sensitive sodium channel subunit beta (Beta-NaCH) (Epithelial Na(+) channel subunit beta) (Beta-ENaC) (ENaCB) (Nonvoltage-gated sodium channel 1 subunit beta) (SCNEB) Amiloride-sensitive sodium channel subunit beta (Beta-NaCH) (Epithelial Na(+) channel subunit beta) (Nonvoltage-gated sodium channel 1 subunit beta) (SCNEB) Epithelial sodium channel beta-2 subunit |
| Synonyms | hCG_23853 |
| Description | FUNCTION: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. . |
| Accessions | ENST00000564275.5 B2R812 ENST00000568085.5 ENST00000568923.5 A0A087WZI2 Q8WY56 Q8WY57 A0A345W497 H3BQ95 ENST00000566441.2 ENST00000307331.9 [P51168-2] ENST00000343070.7 [P51168-1] H3BRM4 P51168 H3BUQ8 |
