Name | Number of supported studies | Average coverage | |
---|---|---|---|
regulatory T cell | 18 studies | 40% ± 17% | |
natural killer cell | 14 studies | 30% ± 16% | |
CD16-negative, CD56-bright natural killer cell, human | 11 studies | 33% ± 14% | |
innate lymphoid cell | 9 studies | 43% ± 20% | |
CD16-positive, CD56-dim natural killer cell, human | 7 studies | 22% ± 10% | |
gamma-delta T cell | 6 studies | 34% ± 13% | |
CD4-positive, alpha-beta T cell | 5 studies | 30% ± 5% | |
CD8-positive, alpha-beta T cell | 5 studies | 26% ± 9% | |
T cell | 4 studies | 22% ± 8% | |
mast cell | 3 studies | 33% ± 13% | |
T follicular helper cell | 3 studies | 30% ± 14% | |
plasma cell | 3 studies | 27% ± 7% | |
group 3 innate lymphoid cell | 3 studies | 43% ± 8% | |
T-helper 17 cell | 3 studies | 29% ± 2% | |
CD4-positive, alpha-beta cytotoxic T cell | 3 studies | 40% ± 13% | |
mature NK T cell | 3 studies | 32% ± 11% |
Insufficient scRNA-seq data for expression of TNFRSF18 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
lung | 94% | 214.22 | 545 / 578 | 83% | 31.88 | 961 / 1155 |
breast | 80% | 116.69 | 369 / 459 | 82% | 25.45 | 920 / 1118 |
prostate | 82% | 136.41 | 202 / 245 | 42% | 5.18 | 211 / 502 |
skin | 72% | 792.61 | 1300 / 1809 | 43% | 5.37 | 202 / 472 |
esophagus | 38% | 105.39 | 554 / 1445 | 71% | 23.46 | 130 / 183 |
intestine | 55% | 199.63 | 528 / 966 | 54% | 7.01 | 282 / 527 |
bladder | 43% | 63.52 | 9 / 21 | 63% | 16.41 | 320 / 504 |
stomach | 52% | 73.96 | 186 / 359 | 53% | 6.79 | 151 / 286 |
uterus | 15% | 42.58 | 25 / 170 | 86% | 45.90 | 395 / 459 |
spleen | 100% | 420.98 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 96% | 61.31 | 43 / 45 |
lymph node | 0% | 0 | 0 / 0 | 93% | 65.14 | 27 / 29 |
peripheral blood | 89% | 518.46 | 823 / 929 | 0% | 0 | 0 / 0 |
thymus | 34% | 59.55 | 221 / 653 | 51% | 7.78 | 307 / 605 |
adipose | 68% | 75.36 | 821 / 1204 | 0% | 0 | 0 / 0 |
pancreas | 1% | 0.91 | 3 / 328 | 60% | 7.55 | 106 / 178 |
kidney | 28% | 40.98 | 25 / 89 | 20% | 2.10 | 177 / 901 |
brain | 41% | 74.73 | 1092 / 2642 | 5% | 0.60 | 35 / 705 |
ovary | 2% | 1.84 | 4 / 180 | 37% | 8.03 | 157 / 430 |
liver | 9% | 6.31 | 20 / 226 | 25% | 3.32 | 100 / 406 |
adrenal gland | 9% | 16.59 | 23 / 258 | 3% | 0.35 | 7 / 230 |
blood vessel | 11% | 13.33 | 141 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 6% | 0.43 | 5 / 80 |
heart | 5% | 5.17 | 46 / 861 | 0% | 0 | 0 / 0 |
muscle | 1% | 0.56 | 6 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0007165 | Biological process | signal transduction |
GO_0006915 | Biological process | apoptotic process |
GO_0042531 | Biological process | positive regulation of tyrosine phosphorylation of STAT protein |
GO_0043066 | Biological process | negative regulation of apoptotic process |
GO_0045785 | Biological process | positive regulation of cell adhesion |
GO_0033209 | Biological process | tumor necrosis factor-mediated signaling pathway |
GO_0002687 | Biological process | positive regulation of leukocyte migration |
GO_0009897 | Cellular component | external side of plasma membrane |
GO_0005576 | Cellular component | extracellular region |
GO_0005886 | Cellular component | plasma membrane |
GO_0005031 | Molecular function | tumor necrosis factor receptor activity |
GO_0005515 | Molecular function | protein binding |
Gene name | TNFRSF18 |
Protein name | Tumor necrosis factor receptor superfamily, member 18 TNF receptor superfamily member 18 Tumor necrosis factor receptor superfamily member 18 isoform 4 Tumor necrosis factor receptor superfamily member 18 (Activation-inducible TNFR family receptor) (Glucocorticoid-induced TNFR-related protein) (CD antigen CD357) |
Synonyms | UNQ319/PRO364 GITR AITR |
Description | FUNCTION: Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway. |
Accessions | ENST00000486728.5 ENST00000379265.5 [Q9Y5U5-3] A8WFP4 J3KT02 Q9Y5U5 ENST00000379268.7 [Q9Y5U5-1] A0A0R7FDM1 ENST00000328596.10 [Q9Y5U5-2] |