Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell of proximal tubule | 3 studies | 27% ± 5% | |
| luminal hormone-sensing cell of mammary gland | 3 studies | 33% ± 4% | |
| epithelial cell | 3 studies | 46% ± 32% | |
| renal alpha-intercalated cell | 3 studies | 42% ± 16% | |
| abnormal cell | 3 studies | 26% ± 11% |
Insufficient scRNA-seq data for expression of PRLR at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 85% | 2734.32 | 390 / 459 | 98% | 78.11 | 1095 / 1118 |
| liver | 96% | 869.45 | 216 / 226 | 73% | 6.40 | 298 / 406 |
| adrenal gland | 100% | 5631.12 | 258 / 258 | 54% | 15.06 | 124 / 230 |
| stomach | 81% | 901.93 | 290 / 359 | 57% | 5.77 | 164 / 286 |
| kidney | 97% | 1416.29 | 86 / 89 | 33% | 4.63 | 294 / 901 |
| uterus | 100% | 6548.24 | 170 / 170 | 24% | 4.84 | 110 / 459 |
| intestine | 58% | 510.01 | 565 / 966 | 59% | 4.84 | 311 / 527 |
| prostate | 86% | 454.66 | 210 / 245 | 30% | 2.24 | 151 / 502 |
| pancreas | 98% | 1081.43 | 321 / 328 | 12% | 2.45 | 21 / 178 |
| ovary | 99% | 1219.59 | 178 / 180 | 8% | 0.61 | 35 / 430 |
| bladder | 71% | 437.48 | 15 / 21 | 27% | 2.26 | 134 / 504 |
| skin | 73% | 775.80 | 1314 / 1809 | 10% | 0.97 | 48 / 472 |
| esophagus | 29% | 98.27 | 421 / 1445 | 30% | 2.99 | 54 / 183 |
| lung | 27% | 66.52 | 156 / 578 | 26% | 2.72 | 303 / 1155 |
| tonsil | 0% | 0 | 0 / 0 | 36% | 2.23 | 16 / 45 |
| brain | 27% | 209.83 | 717 / 2642 | 0% | 0.15 | 3 / 705 |
| peripheral blood | 12% | 100.70 | 114 / 929 | 0% | 0 | 0 / 0 |
| adipose | 12% | 35.06 | 144 / 1204 | 0% | 0 | 0 / 0 |
| heart | 10% | 21.77 | 85 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 8% | 20.11 | 105 / 1335 | 0% | 0 | 0 / 0 |
| thymus | 2% | 14.34 | 11 / 653 | 2% | 0.13 | 14 / 605 |
| spleen | 0% | 1.71 | 1 / 241 | 0% | 0 | 0 / 0 |
| muscle | 0% | 0.19 | 1 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0019221 | Biological process | cytokine-mediated signaling pathway |
| GO_0042976 | Biological process | activation of Janus kinase activity |
| GO_0007171 | Biological process | activation of transmembrane receptor protein tyrosine kinase activity |
| GO_0009617 | Biological process | response to bacterium |
| GO_0060736 | Biological process | prostate gland growth |
| GO_0060749 | Biological process | mammary gland alveolus development |
| GO_0006694 | Biological process | steroid biosynthetic process |
| GO_0097011 | Biological process | cellular response to granulocyte macrophage colony-stimulating factor stimulus |
| GO_0043066 | Biological process | negative regulation of apoptotic process |
| GO_0030890 | Biological process | positive regulation of B cell proliferation |
| GO_0060644 | Biological process | mammary gland epithelial cell differentiation |
| GO_0120162 | Biological process | positive regulation of cold-induced thermogenesis |
| GO_0031954 | Biological process | positive regulation of protein autophosphorylation |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0038161 | Biological process | prolactin signaling pathway |
| GO_0007595 | Biological process | lactation |
| GO_0030155 | Biological process | regulation of cell adhesion |
| GO_0007259 | Biological process | cell surface receptor signaling pathway via JAK-STAT |
| GO_0030856 | Biological process | regulation of epithelial cell differentiation |
| GO_0007566 | Biological process | embryo implantation |
| GO_0009897 | Cellular component | external side of plasma membrane |
| GO_0043235 | Cellular component | receptor complex |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0009986 | Cellular component | cell surface |
| GO_0031904 | Cellular component | endosome lumen |
| GO_0008289 | Molecular function | lipid binding |
| GO_0019955 | Molecular function | cytokine binding |
| GO_0017046 | Molecular function | peptide hormone binding |
| GO_0019901 | Molecular function | protein kinase binding |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0004925 | Molecular function | prolactin receptor activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | PRLR |
| Protein name | Prolactin receptor (PRL-R) Prolactin receptor |
| Synonyms | |
| Description | FUNCTION: This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling. . FUNCTION: This is a receptor for the anterior pituitary hormone prolactin. . FUNCTION: This is a receptor for the anterior pituitary hormone prolactin. . FUNCTION: This is a receptor for the anterior pituitary hormone prolactin. . FUNCTION: This is a receptor for the anterior pituitary hormone prolactin. . FUNCTION: This is a receptor for the anterior pituitary hormone prolactin. . FUNCTION: This is a receptor for the anterior pituitary hormone prolactin. . |
| Accessions | ENST00000618457.5 [P16471-1] ENST00000618625.4 A0A0A7RWZ5 ENST00000348262.7 [P16471-7] Q8TD76 ENST00000310101.9 [P16471-5] ENST00000511486.5 [P16471-2] ENST00000397391.7 D6R9V7 ENST00000619676.4 [P16471-5] P16471 ENST00000514206.5 ENST00000231423.7 [P16471-4] ENST00000620785.4 [P16471-2] D6RAN9 ENST00000515839.1 Q8WWV7 ENST00000509140.5 [P16471-6] ENST00000504500.5 ENST00000508107.5 D6RD41 D6RC67 ENST00000542609.5 [P16471-4] A0A0A7RQI9 D6R9P5 ENST00000513753.5 [P16471-6] ENST00000514088.5 [P16471-7] ENST00000509839.5 D6RJC8 ENST00000503330.5 D6R9E1 |
