FCER1G report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002431Biological processFc receptor mediated stimulatory signaling pathway
GO_0050766Biological processpositive regulation of phagocytosis
GO_0031623Biological processreceptor internalization
GO_0038156Biological processinterleukin-3-mediated signaling pathway
GO_0032753Biological processpositive regulation of interleukin-4 production
GO_0010543Biological processregulation of platelet activation
GO_0045087Biological processinnate immune response
GO_0030593Biological processneutrophil chemotaxis
GO_0038095Biological processFc-epsilon receptor signaling pathway
GO_0071404Biological processcellular response to low-density lipoprotein particle stimulus
GO_0016064Biological processimmunoglobulin mediated immune response
GO_0042742Biological processdefense response to bacterium
GO_0042590Biological processantigen processing and presentation of exogenous peptide antigen via MHC class I
GO_0019886Biological processantigen processing and presentation of exogenous peptide antigen via MHC class II
GO_0002292Biological processT cell differentiation involved in immune response
GO_0038094Biological processFc-gamma receptor signaling pathway
GO_0002283Biological processneutrophil activation involved in immune response
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0033001Cellular componentFc-gamma receptor III complex
GO_0009986Cellular componentcell surface
GO_0070821Cellular componenttertiary granule membrane
GO_0101003Cellular componentficolin-1-rich granule membrane
GO_0032998Cellular componentFc-epsilon receptor I complex
GO_0042803Molecular functionprotein homodimerization activity
GO_0019863Molecular functionIgE binding
GO_0042802Molecular functionidentical protein binding
GO_0019767Molecular functionIgE receptor activity
GO_0019864Molecular functionIgG binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFCER1G
Protein nameHigh affinity immunoglobulin epsilon receptor subunit gamma (Fc receptor gamma-chain) (FcRgamma) (Fc-epsilon RI-gamma) (IgE Fc receptor subunit gamma) (FceRI gamma)
Fc epsilon receptor Ig
Synonyms
DescriptionFUNCTION: Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils, priming T-cells toward effector T-helper 2 subset. Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functional signaling complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of ITAM, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. May function cooperatively with other activating receptors. Functionally linked to integrin beta-2/ITGB2-mediated neutrophil activation. Also involved in integrin alpha-2/ITGA2-mediated platelet activation. .

AccessionsENST00000289902.2
P30273
ENST00000367992.7
A6NCQ8