I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 4 studies | 25% ± 13% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 4 studies | 25% ± 13% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 3 studies | 21% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 96% | 319.68 | 627 / 653 | 96% | 16.09 | 583 / 605 |
| uterus | 93% | 530.31 | 158 / 170 | 92% | 14.70 | 422 / 459 |
| brain | 97% | 2489.59 | 2574 / 2642 | 87% | 13.71 | 613 / 705 |
| liver | 100% | 548.83 | 225 / 226 | 74% | 8.41 | 302 / 406 |
| ovary | 74% | 180.61 | 133 / 180 | 99% | 20.66 | 425 / 430 |
| lung | 74% | 195.98 | 426 / 578 | 87% | 11.82 | 1007 / 1155 |
| pancreas | 77% | 150.09 | 253 / 328 | 79% | 7.35 | 140 / 178 |
| skin | 72% | 429.55 | 1297 / 1809 | 81% | 16.84 | 381 / 472 |
| stomach | 55% | 88.95 | 199 / 359 | 88% | 10.48 | 252 / 286 |
| esophagus | 48% | 109.58 | 691 / 1445 | 92% | 13.31 | 168 / 183 |
| intestine | 47% | 89.54 | 453 / 966 | 88% | 9.45 | 466 / 527 |
| prostate | 64% | 112.50 | 156 / 245 | 58% | 3.13 | 292 / 502 |
| breast | 39% | 64.13 | 180 / 459 | 75% | 5.95 | 839 / 1118 |
| kidney | 62% | 98.07 | 55 / 89 | 50% | 3.15 | 449 / 901 |
| eye | 0% | 0 | 0 / 0 | 100% | 9.72 | 80 / 80 |
| spleen | 100% | 713.89 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 13.85 | 45 / 45 |
| adrenal gland | 62% | 173.02 | 159 / 258 | 26% | 5.84 | 60 / 230 |
| bladder | 5% | 4.71 | 1 / 21 | 75% | 8.44 | 379 / 504 |
| heart | 45% | 74.78 | 387 / 861 | 0% | 0 | 0 / 0 |
| adipose | 40% | 71.68 | 476 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 38% | 83.74 | 508 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 38% | 1.67 | 11 / 29 |
| peripheral blood | 13% | 19.35 | 119 / 929 | 0% | 0 | 0 / 0 |
| muscle | 5% | 8.81 | 43 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0043547 | Biological process | positive regulation of GTPase activity |
| GO_0007409 | Biological process | axonogenesis |
| GO_0010977 | Biological process | negative regulation of neuron projection development |
| GO_0022038 | Biological process | corpus callosum development |
| GO_0023041 | Biological process | neuronal signal transduction |
| GO_0030517 | Biological process | negative regulation of axon extension |
| GO_0048681 | Biological process | negative regulation of axon regeneration |
| GO_0035025 | Biological process | positive regulation of Rho protein signal transduction |
| GO_0007166 | Biological process | cell surface receptor signaling pathway |
| GO_0098978 | Cellular component | glutamatergic synapse |
| GO_0098793 | Cellular component | presynapse |
| GO_0009897 | Cellular component | external side of plasma membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0045121 | Cellular component | membrane raft |
| GO_0043198 | Cellular component | dendritic shaft |
| GO_0043204 | Cellular component | perikaryon |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0043025 | Cellular component | neuronal cell body |
| GO_0043005 | Cellular component | neuron projection |
| GO_0009986 | Cellular component | cell surface |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0044295 | Cellular component | axonal growth cone |
| GO_0008201 | Molecular function | heparin binding |
| GO_0038023 | Molecular function | signaling receptor activity |
| GO_0038131 | Molecular function | neuregulin receptor activity |
| GO_0044877 | Molecular function | protein-containing complex binding |
| GO_1905576 | Molecular function | ganglioside GT1b binding |
| GO_1905573 | Molecular function | ganglioside GM1 binding |
| GO_0035374 | Molecular function | chondroitin sulfate binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | RTN4R |
| Protein name | Reticulon-4 receptor (Nogo receptor) (NgR) (Nogo-66 receptor) Reticulon 4 receptor |
| Synonyms | NOGOR UNQ330/PRO526 |
| Description | FUNCTION: Receptor for RTN4, OMG and MAG . Functions as a receptor for the sialylated gangliosides GT1b and GM1 . Besides, functions as a receptor for chondroitin sulfate proteoglycans (By similarity). Can also bind heparin (By similarity). Intracellular signaling cascades are triggered via the coreceptor NGFR . Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton . Mediates axonal growth inhibition . Plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain development. Required for normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG. Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development . . |
| Accessions | ENST00000043402.8 ENST00000416372.5 ENST00000425986.1 H7C0V4 H7C215 Q9BZR6 |
