CD14 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0031663Biological processlipopolysaccharide-mediated signaling pathway
GO_0006954Biological processinflammatory response
GO_0002752Biological processcell surface pattern recognition receptor signaling pathway
GO_0071727Biological processcellular response to triacyl bacterial lipopeptide
GO_0006898Biological processreceptor-mediated endocytosis
GO_0032026Biological processresponse to magnesium ion
GO_0071726Biological processcellular response to diacyl bacterial lipopeptide
GO_0051602Biological processresponse to electrical stimulus
GO_0045087Biological processinnate immune response
GO_0031666Biological processpositive regulation of lipopolysaccharide-mediated signaling pathway
GO_0071219Biological processcellular response to molecule of bacterial origin
GO_0045807Biological processpositive regulation of endocytosis
GO_0032481Biological processpositive regulation of type I interferon production
GO_0034612Biological processresponse to tumor necrosis factor
GO_0045471Biological processresponse to ethanol
GO_0034145Biological processpositive regulation of toll-like receptor 4 signaling pathway
GO_0071223Biological processcellular response to lipoteichoic acid
GO_0032757Biological processpositive regulation of interleukin-8 production
GO_0034142Biological processtoll-like receptor 4 signaling pathway
GO_0006909Biological processphagocytosis
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0006915Biological processapoptotic process
GO_0032729Biological processpositive regulation of type II interferon production
GO_0001819Biological processpositive regulation of cytokine production
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0007166Biological processcell surface receptor signaling pathway
GO_0005615Cellular componentextracellular space
GO_0030667Cellular componentsecretory granule membrane
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0070062Cellular componentextracellular exosome
GO_0005794Cellular componentGolgi apparatus
GO_0046696Cellular componentlipopolysaccharide receptor complex
GO_0010008Cellular componentendosome membrane
GO_0016019Molecular functionpeptidoglycan immune receptor activity
GO_0001847Molecular functionopsonin receptor activity
GO_0001875Molecular functionlipopolysaccharide immune receptor activity
GO_0001530Molecular functionlipopolysaccharide binding
GO_0005515Molecular functionprotein binding
GO_0070891Molecular functionlipoteichoic acid binding

IV. Literature review

[source]
Gene nameCD14
Protein nameMonocyte differentiation antigen CD14
Monocyte differentiation antigen CD14 (Myeloid cell-specific leucine-rich glycoprotein) (CD antigen CD14) [Cleaved into: Monocyte differentiation antigen CD14, urinary form; Monocyte differentiation antigen CD14, membrane-bound form]
Monocyte differentiation antigen CD14 (Myeloid cell-specific leucine-rich glycoprotein)
Synonyms
DescriptionFUNCTION: Coreceptor for bacterial lipopolysaccharide . In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) . Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response . Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway . Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) . .

FUNCTION: Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-). .

AccessionsD6RFL4
ENST00000519715.2
ENST00000302014.11
ENST00000498971.6
E7EVL5
ENST00000498971.7
ENST00000519715.1
D6RD81
F1C4A7
ENST00000512545.2
P08571
ENST00000512545.1