PDCD1LG2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PDCD1LG2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PDCD1LG2 at tissue level.

III. Associated gene sets

GO_0071222Biological processcellular response to lipopolysaccharide
GO_0031295Biological processT cell costimulation
GO_0032689Biological processnegative regulation of type II interferon production
GO_0006955Biological processimmune response
GO_0002250Biological processadaptive immune response
GO_0042102Biological processpositive regulation of T cell proliferation
GO_0046007Biological processnegative regulation of activated T cell proliferation
GO_0042130Biological processnegative regulation of T cell proliferation
GO_0032693Biological processnegative regulation of interleukin-10 production
GO_0007166Biological processcell surface receptor signaling pathway
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0012505Cellular componentendomembrane system
GO_0005515Molecular functionprotein binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene namePDCD1LG2
Protein nameProgrammed cell death 1 ligand 2 (PD-1 ligand 2) (PD-L2) (PDCD1 ligand 2) (Programmed death ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD antigen CD273)
SynonymsB7DC
PDCD1L2
PDL2
CD273
DescriptionFUNCTION: Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity). .

AccessionsQ9BQ51
ENST00000397747.5 [Q9BQ51-1]