I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell of sinusoid | 3 studies | 26% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell of sinusoid | 3 studies | 26% ± 3% |
Insufficient scRNA-seq data for expression of CLEC4M at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| adrenal gland | 94% | 113.27 | 242 / 258 | 19% | 3.12 | 44 / 230 |
| liver | 100% | 1949.78 | 225 / 226 | 8% | 0.38 | 33 / 406 |
| ovary | 96% | 286.44 | 173 / 180 | 8% | 0.43 | 34 / 430 |
| lung | 91% | 318.36 | 528 / 578 | 1% | 0.03 | 14 / 1155 |
| uterus | 41% | 35.51 | 70 / 170 | 0% | 0.02 | 1 / 459 |
| spleen | 38% | 47.72 | 91 / 241 | 0% | 0 | 0 / 0 |
| prostate | 37% | 15.29 | 90 / 245 | 0% | 0.01 | 1 / 502 |
| kidney | 34% | 13.48 | 30 / 89 | 1% | 0.01 | 5 / 901 |
| bladder | 33% | 21.29 | 7 / 21 | 1% | 0.02 | 3 / 504 |
| thymus | 33% | 14.74 | 217 / 653 | 0% | 0.12 | 3 / 605 |
| intestine | 31% | 29.07 | 303 / 966 | 1% | 0.05 | 4 / 527 |
| adipose | 29% | 28.06 | 346 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 28% | 1.30 | 8 / 29 |
| brain | 21% | 7.43 | 549 / 2642 | 0% | 0.01 | 3 / 705 |
| breast | 19% | 9.12 | 86 / 459 | 1% | 0.03 | 6 / 1118 |
| peripheral blood | 9% | 3.76 | 83 / 929 | 0% | 0 | 0 / 0 |
| skin | 1% | 0.26 | 13 / 1809 | 5% | 0.29 | 22 / 472 |
| stomach | 4% | 1.45 | 15 / 359 | 0% | 0.00 | 1 / 286 |
| esophagus | 4% | 1.23 | 56 / 1445 | 1% | 0.25 | 1 / 183 |
| blood vessel | 3% | 1.21 | 44 / 1335 | 0% | 0 | 0 / 0 |
| heart | 2% | 0.61 | 15 / 861 | 0% | 0 | 0 / 0 |
| pancreas | 0% | 0.08 | 1 / 328 | 1% | 0.01 | 1 / 178 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| muscle | 0% | 0 | 0 / 803 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0044419 | Biological process | biological process involved in interspecies interaction between organisms |
| GO_0075733 | Biological process | intracellular transport of virus |
| GO_0045087 | Biological process | innate immune response |
| GO_0046813 | Biological process | receptor-mediated virion attachment to host cell |
| GO_0006955 | Biological process | immune response |
| GO_0002250 | Biological process | adaptive immune response |
| GO_0046718 | Biological process | symbiont entry into host cell |
| GO_0035556 | Biological process | intracellular signal transduction |
| GO_0019065 | Biological process | receptor-mediated endocytosis of virus by host cell |
| GO_0046968 | Biological process | peptide antigen transport |
| GO_0019882 | Biological process | antigen processing and presentation |
| GO_0019062 | Biological process | virion attachment to host cell |
| GO_0009988 | Biological process | cell-cell recognition |
| GO_0019079 | Biological process | viral genome replication |
| GO_0007159 | Biological process | leukocyte cell-cell adhesion |
| GO_0009897 | Cellular component | external side of plasma membrane |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0043657 | Cellular component | host cell |
| GO_0038023 | Molecular function | signaling receptor activity |
| GO_0005537 | Molecular function | D-mannose binding |
| GO_0030246 | Molecular function | carbohydrate binding |
| GO_0001618 | Molecular function | virus receptor activity |
| GO_0048306 | Molecular function | calcium-dependent protein binding |
| GO_0030369 | Molecular function | ICAM-3 receptor activity |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0046790 | Molecular function | virion binding |
| GO_0042605 | Molecular function | peptide antigen binding |
| Gene name | CLEC4M |
| Protein name | CD209 antigen (Dendritic cell-specific ICAM-3-grabbing non-integrin 1) C-type lectin domain family 4 member M (CD209 antigen-like protein 1) (DC-SIGN-related protein) (DC-SIGNR) (Dendritic cell-specific ICAM-3-grabbing non-integrin 2) (DC-SIGN2) (Liver/lymph node-specific ICAM-3-grabbing non-integrin) (L-SIGN) (CD antigen CD299) C-type lectin domain family 4 member M (CD209 antigen-like protein 1) |
| Synonyms | CD209L1 CD299 CD209L |
| Description | FUNCTION: Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates. .; FUNCTION: (Microbial infection) Acts as an attachment receptor for Ebolavirus. .; FUNCTION: (Microbial infection) Acts as an attachment receptor for Hepatitis C virus. .; FUNCTION: (Microbial infection) Acts as an attachment receptor for HIV-1. .; FUNCTION: (Microbial infection) Acts as an attachment receptor for Human coronavirus 229E. .; FUNCTION: (Microbial infection) Acts as an attachment receptor for Human cytomegalovirus/HHV-5. .; FUNCTION: (Microbial infection) Acts as an attachment receptor for Influenzavirus. .; FUNCTION: (Microbial infection) Acts as an attachment receptor for SARS-CoV. .; FUNCTION: (Microbial infection) Acts as an attachment receptor for West-nile virus. .; FUNCTION: (Microbial infection) Acts as an attachment receptor for Japanese encephalitis virus. .; FUNCTION: (Microbial infection) Acts as an attachment receptor for Marburg virus glycoprotein. .; FUNCTION: (Microbial infection) Recognition of M.bovis by dendritic cells may occur partially via this molecule. . FUNCTION: On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells. . |
| Accessions | Q9H2X3 ENST00000394122.7 A0A7P0MMK7 Q2TB20 E7ENS9 ENST00000596363.5 [Q9H2X3-9] ENST00000327325.10 [Q9H2X3-1] ENST00000359059.10 |
