IZUMO1R report

I. Expression across cell types

Insufficient scRNA-seq data for expression of IZUMO1R at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IZUMO1R at tissue level.

III. Associated gene sets

GO_0007338Biological processsingle fertilization
GO_0007155Biological processcell adhesion
GO_0035036Biological processsperm-egg recognition
GO_0007342Biological processfusion of sperm to egg plasma membrane involved in single fertilization
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0031528Cellular componentmicrovillus membrane
GO_0005542Molecular functionfolic acid binding
GO_0038023Molecular functionsignaling receptor activity
GO_0005102Molecular functionsignaling receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameIZUMO1R
Protein nameSperm-egg fusion protein Juno (Folate receptor 4) (Folate receptor delta) (FR-delta) (IZUMO1 receptor protein JUNO)
SynonymsFOLR4
JUNO
DescriptionFUNCTION: Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate. .

AccessionsA6ND01
ENST00000328458.6 [A6ND01-1]
ENST00000687084.1 [A6ND01-1]
ENST00000440961.6 [A6ND01-2]