ST14 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030216Biological processkeratinocyte differentiation
GO_0006508Biological processproteolysis
GO_0001843Biological processneural tube closure
GO_0030163Biological processprotein catabolic process
GO_0060672Biological processepithelial cell morphogenesis involved in placental branching
GO_0005615Cellular componentextracellular space
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0016323Cellular componentbasolateral plasma membrane
GO_0008236Molecular functionserine-type peptidase activity
GO_0004252Molecular functionserine-type endopeptidase activity

IV. Literature review

[source]
Gene nameST14
Protein nameST14 protein
Suppressor of tumorigenicity 14 protein (EC 3.4.21.109) (Matriptase) (Membrane-type serine protease 1) (MT-SP1) (Prostamin) (Serine protease 14) (Serine protease TADG-15) (Tumor-associated differentially-expressed gene 15 protein)
SynonymsSNC19
PRSS14
TADG15
DescriptionFUNCTION: Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site . Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing . Proteolytically cleaves and therefore activates TMPRSS13 . .

AccessionsENST00000278742.6
Q8WVC1
Q9Y5Y6