ITGA2B | OmnibusX

Name	Number of supported studies	Average coverage
platelet	10 studies	54% ± 17%	Explore
megakaryocyte	6 studies	77% ± 22%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	60% ± 18%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of ITGA2B at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	96%	339.18	173 / 180	70%	1.77	301 / 430
thymus	99%	763.85	649 / 653	59%	1.31	357 / 605
uterus	91%	331.38	155 / 170	65%	3.18	299 / 459
brain	77%	238.34	2037 / 2642	52%	1.02	368 / 705
lung	99%	1018.28	570 / 578	30%	0.83	341 / 1155
spleen	100%	1832.07	241 / 241	0%	0	0 / 0
kidney	72%	136.47	64 / 89	21%	0.80	186 / 901
breast	68%	93.48	313 / 459	20%	0.44	226 / 1118
peripheral blood	81%	4508.07	757 / 929	0%	0	0 / 0
prostate	78%	154.29	190 / 245	1%	0.04	4 / 502
adipose	69%	118.23	834 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	53%	1.91	24 / 45
esophagus	38%	51.40	542 / 1445	15%	0.33	27 / 183
heart	48%	114.84	414 / 861	0%	0	0 / 0
intestine	35%	44.91	336 / 966	4%	0.11	19 / 527
bladder	14%	20.43	3 / 21	15%	0.54	77 / 504
stomach	24%	35.69	87 / 359	3%	0.05	10 / 286
liver	19%	25.77	42 / 226	6%	0.11	23 / 406
adrenal gland	10%	10.19	25 / 258	12%	0.19	27 / 230
skin	3%	3.12	52 / 1809	13%	0.32	59 / 472
blood vessel	10%	14.90	138 / 1335	0%	0	0 / 0
pancreas	1%	1.21	3 / 328	6%	0.13	11 / 178
eye	0%	0	0 / 0	1%	0.02	1 / 80
muscle	1%	0.94	7 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0001525	Biological process	angiogenesis
GO_0033627	Biological process	cell adhesion mediated by integrin
GO_0007160	Biological process	cell-matrix adhesion
GO_0007229	Biological process	integrin-mediated signaling pathway
GO_0002687	Biological process	positive regulation of leukocyte migration
GO_0098609	Biological process	cell-cell adhesion
GO_0009897	Cellular component	external side of plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0008305	Cellular component	integrin complex
GO_0070062	Cellular component	extracellular exosome
GO_0005925	Cellular component	focal adhesion
GO_0031092	Cellular component	platelet alpha granule membrane
GO_0072562	Cellular component	blood microparticle
GO_0009986	Cellular component	cell surface
GO_0070442	Cellular component	integrin alphaIIb-beta3 complex
GO_0070051	Molecular function	fibrinogen binding
GO_0060090	Molecular function	molecular adaptor activity
GO_0042802	Molecular function	identical protein binding
GO_0005178	Molecular function	integrin binding
GO_0046872	Molecular function	metal ion binding
GO_0050840	Molecular function	extracellular matrix binding
GO_0005515	Molecular function	protein binding

Gene name	ITGA2B
Protein name	Integrin alpha-IIb (GPalpha IIb) (GPIIb) (Platelet membrane glycoprotein IIb) (CD antigen CD41) [Cleaved into: Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain, form 1; Integrin alpha-IIb light chain, form 2] Integrin subunit alpha 2b Platelet glycoprotein IIb Glycoprotein IIb
Synonyms	ITGAB GP2B
Description	FUNCTION: Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
Accessions	F1C626 ENST00000587295.5 P08514 ENST00000262407.6 [P08514-1] ENST00000648408.1 A0A3B3IU79 I6XCH0 Q6LDK5 F1C625 K7EP83

ITGA2B report