HHLA2 | OmnibusX

Name	Number of supported studies	Average coverage
ciliated cell	8 studies	33% ± 13%	Explore
enterocyte	4 studies	24% ± 2%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of HHLA2 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
kidney	98%	395.33	87 / 89	78%	51.46	707 / 901
pancreas	96%	100.82	316 / 328	71%	15.46	127 / 178
intestine	72%	2559.95	700 / 966	85%	27.42	447 / 527
stomach	65%	107.05	232 / 359	78%	22.26	222 / 286
lung	81%	162.40	469 / 578	27%	14.95	310 / 1155
spleen	68%	19.72	165 / 241	0%	0	0 / 0
brain	51%	13.36	1343 / 2642	0%	0	0 / 705
esophagus	6%	2.90	82 / 1445	36%	15.10	66 / 183
prostate	38%	12.02	94 / 245	0%	0.01	1 / 502
peripheral blood	34%	15.27	316 / 929	0%	0	0 / 0
bladder	0%	0	0 / 21	24%	9.42	121 / 504
uterus	6%	5.72	10 / 170	5%	1.56	24 / 459
liver	7%	2.48	16 / 226	2%	0.20	9 / 406
ovary	4%	1.11	8 / 180	2%	0.14	7 / 430
thymus	5%	1.19	31 / 653	0%	0	0 / 605
breast	3%	18.04	16 / 459	0%	0	0 / 1118
adipose	2%	0.59	21 / 1204	0%	0	0 / 0
adrenal gland	2%	0.22	4 / 258	0%	0	0 / 230
skin	1%	0.27	19 / 1809	0%	0.01	1 / 472
blood vessel	1%	0.61	12 / 1335	0%	0	0 / 0
heart	0%	0.06	3 / 861	0%	0	0 / 0
muscle	0%	0.02	1 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0031295	Biological process	T cell costimulation
GO_0042104	Biological process	positive regulation of activated T cell proliferation
GO_0001819	Biological process	positive regulation of cytokine production
GO_0050852	Biological process	T cell receptor signaling pathway
GO_0001817	Biological process	regulation of cytokine production
GO_0005575	Cellular component	cellular_component
GO_0009897	Cellular component	external side of plasma membrane
GO_0005102	Molecular function	signaling receptor binding
GO_0005515	Molecular function	protein binding
GO_0003674	Molecular function	molecular_function

Gene name	HHLA2
Protein name	HERV-H LTR-associating protein 2 (Human endogenous retrovirus-H long terminal repeat-associating protein 2) HERV-H LTR-associating 2
Synonyms
Description	FUNCTION: Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade. .
Accessions	C9JD07 C9JY43 ENST00000467282.5 C9JY13 ENST00000462629.5 ENST00000491820.5 C9J7D0 ENST00000467562.5 [Q9UM44-2] H7C523 Q9UM44 ENST00000482099.1 ENST00000463019.7 ENST00000357759.9 [Q9UM44-1] ENST00000467761.6 [Q9UM44-1] ENST00000489514.6 [Q9UM44-1]

HHLA2 report