KDR | OmnibusX

Name	Number of supported studies	Average coverage
endothelial cell	37 studies	34% ± 17%	Explore
endothelial cell of lymphatic vessel	17 studies	35% ± 14%	Explore
capillary endothelial cell	14 studies	34% ± 16%	Explore
vein endothelial cell	8 studies	27% ± 11%	Explore
endothelial cell of artery	6 studies	43% ± 18%	Explore
Mueller cell	6 studies	52% ± 13%	Explore
endothelial cell of vascular tree	6 studies	31% ± 15%	Explore
glomerular endothelial cell	4 studies	68% ± 10%	Explore
mesothelial cell	4 studies	23% ± 1%	Explore
club cell	3 studies	26% ± 10%	Explore
endothelial cell of sinusoid	3 studies	51% ± 33%	Explore

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of KDR at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	7733.09	459 / 459	97%	24.98	1083 / 1118
thymus	100%	10976.08	653 / 653	92%	47.98	559 / 605
adrenal gland	99%	3190.33	255 / 258	89%	28.90	205 / 230
lung	100%	7043.97	577 / 578	88%	23.88	1015 / 1155
prostate	98%	3671.00	240 / 245	87%	14.84	438 / 502
stomach	93%	1882.72	334 / 359	85%	13.36	243 / 286
kidney	100%	3809.36	89 / 89	76%	91.45	683 / 901
bladder	95%	2481.62	20 / 21	72%	9.64	362 / 504
esophagus	84%	2365.30	1212 / 1445	79%	12.56	145 / 183
intestine	85%	1718.34	824 / 966	76%	10.20	399 / 527
uterus	100%	10754.09	170 / 170	54%	6.52	250 / 459
pancreas	60%	767.77	197 / 328	87%	15.22	154 / 178
skin	63%	1237.70	1143 / 1809	81%	14.79	384 / 472
brain	32%	413.82	852 / 2642	89%	13.47	630 / 705
liver	46%	872.51	104 / 226	74%	11.36	300 / 406
ovary	68%	1330.49	123 / 180	51%	4.83	218 / 430
adipose	100%	9147.81	1204 / 1204	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	10.42	1 / 1
heart	97%	2849.28	838 / 861	0%	0	0 / 0
spleen	81%	1192.35	196 / 241	0%	0	0 / 0
blood vessel	81%	2057.83	1080 / 1335	0%	0	0 / 0
muscle	66%	889.24	527 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	53%	7.88	24 / 45
lymph node	0%	0	0 / 0	41%	3.84	12 / 29
eye	0%	0	0 / 0	38%	4.85	30 / 80
peripheral blood	0%	1.48	1 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_1901532	Biological process	regulation of hematopoietic progenitor cell differentiation
GO_0001541	Biological process	ovarian follicle development
GO_0007275	Biological process	multicellular organism development
GO_0003157	Biological process	endocardium development
GO_0038084	Biological process	vascular endothelial growth factor signaling pathway
GO_0002053	Biological process	positive regulation of mesenchymal cell proliferation
GO_0043129	Biological process	surfactant homeostasis
GO_0030513	Biological process	positive regulation of BMP signaling pathway
GO_0051897	Biological process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_1903010	Biological process	regulation of bone development
GO_0060837	Biological process	blood vessel endothelial cell differentiation
GO_0050927	Biological process	positive regulation of positive chemotaxis
GO_0070374	Biological process	positive regulation of ERK1 and ERK2 cascade
GO_0035924	Biological process	cellular response to vascular endothelial growth factor stimulus
GO_0072089	Biological process	stem cell proliferation
GO_0050673	Biological process	epithelial cell proliferation
GO_0001525	Biological process	angiogenesis
GO_2000352	Biological process	negative regulation of endothelial cell apoptotic process
GO_0051901	Biological process	positive regulation of mitochondrial depolarization
GO_0010629	Biological process	negative regulation of gene expression
GO_0045766	Biological process	positive regulation of angiogenesis
GO_0090050	Biological process	positive regulation of cell migration involved in sprouting angiogenesis
GO_0045165	Biological process	cell fate commitment
GO_0016239	Biological process	positive regulation of macroautophagy
GO_0010463	Biological process	mesenchymal cell proliferation
GO_2001214	Biological process	positive regulation of vasculogenesis
GO_1904881	Biological process	cellular response to hydrogen sulfide
GO_0001945	Biological process	lymph vessel development
GO_0046777	Biological process	protein autophosphorylation
GO_0035162	Biological process	embryonic hemopoiesis
GO_0051770	Biological process	positive regulation of nitric-oxide synthase biosynthetic process
GO_0045446	Biological process	endothelial cell differentiation
GO_0043536	Biological process	positive regulation of blood vessel endothelial cell migration
GO_0048597	Biological process	post-embryonic camera-type eye morphogenesis
GO_0001570	Biological process	vasculogenesis
GO_0001934	Biological process	positive regulation of protein phosphorylation
GO_0038083	Biological process	peptidyl-tyrosine autophosphorylation
GO_0002070	Biological process	epithelial cell maturation
GO_0033674	Biological process	positive regulation of kinase activity
GO_0001569	Biological process	branching involved in blood vessel morphogenesis
GO_2001028	Biological process	positive regulation of endothelial cell chemotaxis
GO_0003158	Biological process	endothelium development
GO_0051894	Biological process	positive regulation of focal adhesion assembly
GO_0048010	Biological process	vascular endothelial growth factor receptor signaling pathway
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0043524	Biological process	negative regulation of neuron apoptotic process
GO_0016477	Biological process	cell migration
GO_0048286	Biological process	lung alveolus development
GO_0055074	Biological process	calcium ion homeostasis
GO_0090141	Biological process	positive regulation of mitochondrial fission
GO_0007169	Biological process	cell surface receptor protein tyrosine kinase signaling pathway
GO_0002042	Biological process	cell migration involved in sprouting angiogenesis
GO_0010595	Biological process	positive regulation of endothelial cell migration
GO_2000648	Biological process	positive regulation of stem cell proliferation
GO_0043410	Biological process	positive regulation of MAPK cascade
GO_0018108	Biological process	peptidyl-tyrosine phosphorylation
GO_0001938	Biological process	positive regulation of endothelial cell proliferation
GO_0030335	Biological process	positive regulation of cell migration
GO_0036324	Biological process	vascular endothelial growth factor receptor-2 signaling pathway
GO_0008360	Biological process	regulation of cell shape
GO_0061042	Biological process	vascular wound healing
GO_0071526	Biological process	semaphorin-plexin signaling pathway
GO_0043408	Biological process	regulation of MAPK cascade
GO_0045121	Cellular component	membrane raft
GO_0005768	Cellular component	endosome
GO_0005634	Cellular component	nucleus
GO_0005576	Cellular component	extracellular region
GO_0009897	Cellular component	external side of plasma membrane
GO_0043235	Cellular component	receptor complex
GO_0005886	Cellular component	plasma membrane
GO_0005769	Cellular component	early endosome
GO_0005794	Cellular component	Golgi apparatus
GO_0097443	Cellular component	sorting endosome
GO_0005783	Cellular component	endoplasmic reticulum
GO_0070161	Cellular component	anchoring junction
GO_0030054	Cellular component	cell junction
GO_0005021	Molecular function	vascular endothelial growth factor receptor activity
GO_0051879	Molecular function	Hsp90 protein binding
GO_0042802	Molecular function	identical protein binding
GO_0005524	Molecular function	ATP binding
GO_0015026	Molecular function	coreceptor activity
GO_0038085	Molecular function	vascular endothelial growth factor binding
GO_0004713	Molecular function	protein tyrosine kinase activity
GO_0005515	Molecular function	protein binding
GO_0045296	Molecular function	cadherin binding
GO_0004714	Molecular function	transmembrane receptor protein tyrosine kinase activity
GO_0005178	Molecular function	integrin binding
GO_0019838	Molecular function	growth factor binding

IV. Literature review

[source]

Gene name	KDR
Protein name	Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309) Kinase insert domain receptor (EC 2.7.10.1) Vascular endothelial growth factor receptor 2 (EC 2.7.10.1) Vascular endothelial growth factor receptor 2 variant (EC 2.7.10.1)
Synonyms	FLK1 VEGFR2
Description	FUNCTION: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC. .
Accessions	A0A0U2X4C8 A0A0H4AF76 ENST00000263923.5 [P35968-1] A0A0H4A777 A0A0H4A7S0 A0A0U2WZU8 A0A0H4ADZ1 A0A0H4A7S4 P35968 A0A0U2VU55 A0A0H4AF85

KDR report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review