THBD report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010544Biological processnegative regulation of platelet activation
GO_0010165Biological processresponse to X-ray
GO_0051918Biological processnegative regulation of fibrinolysis
GO_0072377Biological processblood coagulation, common pathway
GO_0007596Biological processblood coagulation
GO_0007565Biological processfemale pregnancy
GO_0031638Biological processzymogen activation
GO_0051591Biological processresponse to cAMP
GO_0006508Biological processproteolysis
GO_0030195Biological processnegative regulation of blood coagulation
GO_0032496Biological processresponse to lipopolysaccharide
GO_0005615Cellular componentextracellular space
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0009986Cellular componentcell surface
GO_0005774Cellular componentvacuolar membrane
GO_1905370Cellular componentserine-type endopeptidase complex
GO_0016327Cellular componentapicolateral plasma membrane
GO_0038023Molecular functionsignaling receptor activity
GO_0004888Molecular functiontransmembrane signaling receptor activity
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTHBD
Protein nameThrombomodulin (TM) (Fetomodulin) (CD antigen CD141)
SynonymsTHRM
DescriptionFUNCTION: Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.

AccessionsENST00000377103.3
P07204