CD33 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0150102Biological processnegative regulation of monocyte activation
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0007165Biological processsignal transduction
GO_0007155Biological processcell adhesion
GO_0032691Biological processnegative regulation of interleukin-1 beta production
GO_0007267Biological processcell-cell signaling
GO_0050714Biological processpositive regulation of protein secretion
GO_0032717Biological processnegative regulation of interleukin-8 production
GO_0002765Biological processimmune response-inhibiting signal transduction
GO_0032720Biological processnegative regulation of tumor necrosis factor production
GO_0098609Biological processcell-cell adhesion
GO_0038094Biological processFc-gamma receptor signaling pathway
GO_0009897Cellular componentexternal side of plasma membrane
GO_0035579Cellular componentspecific granule membrane
GO_0005886Cellular componentplasma membrane
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0005777Cellular componentperoxisome
GO_0070821Cellular componenttertiary granule membrane
GO_0038023Molecular functionsignaling receptor activity
GO_0019903Molecular functionprotein phosphatase binding
GO_0033691Molecular functionsialic acid binding
GO_0030246Molecular functioncarbohydrate binding
GO_0008160Molecular functionprotein tyrosine phosphatase activator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCD33
Protein nameMyeloid cell surface antigen CD33 (Sialic acid-binding Ig-like lectin 3) (Siglec-3) (gp67) (CD antigen CD33)
CD33 molecule (cDNA FLJ50122, highly similar to Myeloid cell surface antigen CD33)
CD33 molecule transcript variant
CD33 antigen (Gp67)
SynonymshCG_91950
SIGLEC3
DescriptionFUNCTION: Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state . Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans . Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK . These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 . In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules . One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K . .

AccessionsENST00000391796.7 [P20138-2]
Q546G0
ENST00000436584.6
ENST00000262262.5 [P20138-1]
ENST00000421133.6 [P20138-3]
A0A173G4N9
P20138
B4DF51