CD9 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008285Biological processnegative regulation of cell population proliferation
GO_0031623Biological processreceptor internalization
GO_0014905Biological processmyoblast fusion involved in skeletal muscle regeneration
GO_0008283Biological processcell population proliferation
GO_0035036Biological processsperm-egg recognition
GO_0007155Biological processcell adhesion
GO_0090331Biological processnegative regulation of platelet aggregation
GO_0030168Biological processplatelet activation
GO_0071404Biological processcellular response to low-density lipoprotein particle stimulus
GO_0008347Biological processglial cell migration
GO_1905521Biological processregulation of macrophage migration
GO_0030913Biological processparanodal junction assembly
GO_0007342Biological processfusion of sperm to egg plasma membrane involved in single fertilization
GO_0005615Cellular componentextracellular space
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0030666Cellular componentendocytic vesicle membrane
GO_0070062Cellular componentextracellular exosome
GO_0032991Cellular componentprotein-containing complex
GO_1903561Cellular componentextracellular vesicle
GO_0030669Cellular componentclathrin-coated endocytic vesicle membrane
GO_0005925Cellular componentfocal adhesion
GO_0031092Cellular componentplatelet alpha granule membrane
GO_0005178Molecular functionintegrin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCD9
Protein nameTetraspanin
CD9 molecule
CD9 antigen (5H9 antigen) (Cell growth-inhibiting gene 2 protein) (Leukocyte antigen MIC3) (Motility-related protein) (MRP-1) (Tetraspanin-29) (Tspan-29) (p24) (CD antigen CD9)
SynonymsTSPAN29
MIC3
GIG2
DescriptionFUNCTION: Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion . Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD81 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles . Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption (By similarity). Acts as a receptor for PSG17 (By similarity). Involved in platelet activation and aggregation . Regulates paranodal junction formation (By similarity). Involved in cell adhesion, cell motility and tumor metastasis . .

AccessionsA0A087WU13
ENST00000536586.7
F5GXT1
G8JLH6
ENST00000610354.5
ENST00000676764.1
ENST00000679331.1
ENST00000677572.1
ENST00000382515.7
P21926
A0A7I2V3T7
ENST00000382518.6
ENST00000538834.6
ENST00000645565.1
ENST00000642746.1
ENST00000009180.10
ENST00000646407.1
A6NNI4
A0A7I2V3T0
ENST00000382519.9
A0A2R8Y478