IL17A report

I. Expression across cell types

Insufficient scRNA-seq data for expression of IL17A at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IL17A at tissue level.

III. Associated gene sets

GO_0030216Biological processkeratinocyte differentiation
GO_0050832Biological processdefense response to fungus
GO_0097530Biological processgranulocyte migration
GO_0072537Biological processfibroblast activation
GO_0006954Biological processinflammatory response
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0007219Biological processNotch signaling pathway
GO_2000340Biological processpositive regulation of chemokine (C-X-C motif) ligand 1 production
GO_0038173Biological processinterleukin-17A-mediated signaling pathway
GO_0008219Biological processcell death
GO_0045087Biological processinnate immune response
GO_0032747Biological processpositive regulation of interleukin-23 production
GO_0050829Biological processdefense response to Gram-negative bacterium
GO_0032735Biological processpositive regulation of interleukin-12 production
GO_0002225Biological processpositive regulation of antimicrobial peptide production
GO_0071347Biological processcellular response to interleukin-1
GO_1903348Biological processpositive regulation of bicellular tight junction assembly
GO_0007267Biological processcell-cell signaling
GO_1900017Biological processpositive regulation of cytokine production involved in inflammatory response
GO_0045672Biological processpositive regulation of osteoclast differentiation
GO_0032731Biological processpositive regulation of interleukin-1 beta production
GO_0006955Biological processimmune response
GO_0002250Biological processadaptive immune response
GO_0050830Biological processdefense response to Gram-positive bacterium
GO_0006915Biological processapoptotic process
GO_0010467Biological processgene expression
GO_0106015Biological processnegative regulation of inflammatory response to wounding
GO_0060729Biological processintestinal epithelial structure maintenance
GO_0032739Biological processpositive regulation of interleukin-16 production
GO_0009611Biological processresponse to wounding
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0043616Biological processkeratinocyte proliferation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0097400Biological processinterleukin-17-mediated signaling pathway
GO_0005615Cellular componentextracellular space
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005576Cellular componentextracellular region
GO_0042803Molecular functionprotein homodimerization activity
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005515Molecular functionprotein binding
GO_0005125Molecular functioncytokine activity

IV. Literature review

[source]
Gene nameIL17A
Protein nameInterleukin 17A
Interleukin-17A (IL-17) (IL-17A) (Cytotoxic T-lymphocyte-associated antigen 8) (CTLA-8)
SynonymsCTLA8
IL17
DescriptionFUNCTION: Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity . Signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation . Plays an important role in connecting T cell-mediated adaptive immunity and acute inflammatory response to destroy extracellular bacteria and fungi. As a signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites (By similarity). In airway epithelium, mediates neutrophil chemotaxis via induction of CXCL1 and CXCL5 chemokines (By similarity). In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells (By similarity). Effector cytokine of a subset of gamma-delta T cells that functions as part of an inflammatory circuit downstream IL1B, TLR2 and IL23A-IL12B to promote neutrophil recruitment for efficient bacterial clearance (By similarity). Effector cytokine of innate immune cells including invariant natural killer cell (iNKT) and group 3 innate lymphoid cells that mediate initial neutrophilic inflammation (By similarity). Involved in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection . Upon acute injury, has a direct role in epithelial barrier formation by regulating OCLN localization and tight junction biogenesis (By similarity). As part of the mucosal immune response induced by commensal bacteria, enhances host's ability to resist pathogenic bacterial and fungal infections by promoting neutrophil recruitment and antimicrobial peptides release (By similarity). In synergy with IL17F, mediates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity). Involved in antiviral host defense through various mechanisms (By similarity). Enhances immunity against West Nile virus by promoting T cell cytotoxicity (By similarity). May play a beneficial role in influenza A virus (H5N1) infection by enhancing B cell recruitment and immune response in the lung (By similarity). Contributes to influenza A virus (H1N1) clearance by driving the differentiation of B-1a B cells, providing for production of virus-specific IgM antibodies at first line of host defense (By similarity). .

AccessionsQ16552
Q6NZ94
ENST00000648244.1