GHR | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	11 studies	31% ± 11%	Explore
oligodendrocyte precursor cell	11 studies	35% ± 14%	Explore
adipocyte	11 studies	78% ± 12%	Explore
fibroblast	11 studies	30% ± 9%	Explore
glutamatergic neuron	8 studies	35% ± 18%	Explore
pericyte	8 studies	30% ± 10%	Explore
smooth muscle cell	7 studies	30% ± 9%	Explore
astrocyte	6 studies	31% ± 17%	Explore
hepatocyte	5 studies	59% ± 32%	Explore
GABAergic neuron	5 studies	39% ± 14%	Explore
cardiac muscle cell	5 studies	31% ± 8%	Explore
mesothelial cell	3 studies	38% ± 15%	Explore
connective tissue cell	3 studies	21% ± 6%	Explore
interneuron	3 studies	42% ± 14%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	5 studies	34% ± 18%	Explore
heart	4 studies	24% ± 4%	Explore
liver	3 studies	29% ± 12%	Explore
adipose	3 studies	33% ± 12%	Explore
kidney	3 studies	20% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	94%	1279.18	231 / 245	97%	27.73	489 / 502
liver	100%	7602.15	226 / 226	88%	20.15	359 / 406
breast	99%	6665.72	455 / 459	84%	9.92	939 / 1118
kidney	93%	925.31	83 / 89	65%	7.25	587 / 901
adrenal gland	88%	919.14	227 / 258	66%	6.77	151 / 230
thymus	94%	1133.69	617 / 653	36%	3.39	219 / 605
lung	86%	889.05	495 / 578	38%	3.24	434 / 1155
skin	88%	1148.51	1596 / 1809	28%	2.09	134 / 472
intestine	87%	1116.45	838 / 966	24%	1.13	128 / 527
uterus	79%	699.59	135 / 170	31%	2.12	140 / 459
bladder	95%	1101.10	20 / 21	13%	0.67	66 / 504
ovary	81%	786.79	145 / 180	24%	1.02	102 / 430
esophagus	68%	720.19	982 / 1445	36%	2.81	66 / 183
stomach	78%	1079.29	279 / 359	26%	1.57	74 / 286
adipose	100%	9660.48	1204 / 1204	0%	0	0 / 0
muscle	100%	5815.22	803 / 803	0%	0	0 / 0
blood vessel	97%	1342.73	1294 / 1335	0%	0	0 / 0
heart	79%	882.54	682 / 861	0%	0	0 / 0
spleen	57%	488.80	137 / 241	0%	0	0 / 0
pancreas	11%	67.73	35 / 328	46%	2.59	82 / 178
brain	3%	23.30	70 / 2642	51%	2.18	357 / 705
tonsil	0%	0	0 / 0	40%	2.41	18 / 45
eye	0%	0	0 / 0	3%	0.09	2 / 80
peripheral blood	0%	2.77	4 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0042531	Biological process	positive regulation of tyrosine phosphorylation of STAT protein
GO_0019221	Biological process	cytokine-mediated signaling pathway
GO_0006897	Biological process	endocytosis
GO_0032869	Biological process	cellular response to insulin stimulus
GO_0048009	Biological process	insulin-like growth factor receptor signaling pathway
GO_0060396	Biological process	growth hormone receptor signaling pathway
GO_0032870	Biological process	cellular response to hormone stimulus
GO_0032107	Biological process	regulation of response to nutrient levels
GO_0070555	Biological process	response to interleukin-1
GO_0040014	Biological process	regulation of multicellular organism growth
GO_0043406	Biological process	positive regulation of MAP kinase activity
GO_0019530	Biological process	taurine metabolic process
GO_0045597	Biological process	positive regulation of cell differentiation
GO_0051384	Biological process	response to glucocorticoid
GO_0050731	Biological process	positive regulation of peptidyl-tyrosine phosphorylation
GO_0040018	Biological process	positive regulation of multicellular organism growth
GO_0009629	Biological process	response to gravity
GO_0009755	Biological process	hormone-mediated signaling pathway
GO_0032094	Biological process	response to food
GO_0042445	Biological process	hormone metabolic process
GO_0046427	Biological process	positive regulation of receptor signaling pathway via JAK-STAT
GO_0060351	Biological process	cartilage development involved in endochondral bone morphogenesis
GO_0007259	Biological process	cell surface receptor signaling pathway via JAK-STAT
GO_0005615	Cellular component	extracellular space
GO_0009897	Cellular component	external side of plasma membrane
GO_0043235	Cellular component	receptor complex
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0036464	Cellular component	cytoplasmic ribonucleoprotein granule
GO_0043025	Cellular component	neuronal cell body
GO_0070195	Cellular component	growth hormone receptor complex
GO_0009986	Cellular component	cell surface
GO_0005829	Cellular component	cytosol
GO_0042803	Molecular function	protein homodimerization activity
GO_0008289	Molecular function	lipid binding
GO_0019903	Molecular function	protein phosphatase binding
GO_0070064	Molecular function	proline-rich region binding
GO_0019955	Molecular function	cytokine binding
GO_0017046	Molecular function	peptide hormone binding
GO_0019901	Molecular function	protein kinase binding
GO_0042802	Molecular function	identical protein binding
GO_0042169	Molecular function	SH2 domain binding
GO_0004903	Molecular function	growth hormone receptor activity
GO_0019838	Molecular function	growth factor binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	GHR
Protein name	GHR protein Growth hormone receptor (Somatotropin receptor) Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)] Growth hormone receptor Mutant growth hormone receptor Truncated growth hormone receptor
Synonyms
Description	FUNCTION: Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity). .; FUNCTION: The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.; FUNCTION: Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling. FUNCTION: The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. .
Accessions	E7ES05 E9PCN7 ENST00000537449.5 [P10912-1] ENST00000513671.5 ENST00000615111.4 [P10912-1] ENST00000612626.4 [P10912-1] A0A8A6U7T3 A0A087X162 A0A8A6UB81 A0A087X0H5 P10912 ENST00000618088.4 [P10912-1] ENST00000357703.6 [P10912-4] Q9NRZ8 ENST00000620156.4 A0A8A6UC02 ENST00000612382.4 [P10912-1] ENST00000511135.5 B9EGJ3 ENST00000230882.9 [P10912-1] ENST00000622294.2 Q9HCW9

GHR report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review