CA4 | OmnibusX

Name	Number of supported studies	Average coverage
capillary endothelial cell	14 studies	48% ± 22%	Explore
endothelial cell	9 studies	28% ± 9%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of CA4 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	99%	3728.17	644 / 653	62%	15.04	377 / 605
brain	60%	1322.95	1590 / 2642	90%	20.16	637 / 705
kidney	98%	1755.10	87 / 89	49%	8.92	438 / 901
lung	99%	4053.39	570 / 578	27%	2.25	307 / 1155
pancreas	81%	722.51	265 / 328	44%	5.28	78 / 178
breast	89%	3577.35	407 / 459	11%	0.66	122 / 1118
adipose	95%	2966.04	1141 / 1204	0%	0	0 / 0
intestine	42%	2208.71	404 / 966	47%	17.79	246 / 527
prostate	38%	279.40	92 / 245	36%	2.01	181 / 502
stomach	32%	193.67	116 / 359	38%	12.27	109 / 286
peripheral blood	66%	3415.91	613 / 929	0%	0	0 / 0
spleen	65%	649.91	157 / 241	0%	0	0 / 0
eye	0%	0	0 / 0	64%	3.38	51 / 80
heart	61%	681.58	523 / 861	0%	0	0 / 0
bladder	24%	146.90	5 / 21	32%	8.72	163 / 504
adrenal gland	2%	18.62	6 / 258	44%	5.05	102 / 230
uterus	31%	375.69	53 / 170	11%	1.26	52 / 459
ovary	22%	175.39	40 / 180	13%	1.18	56 / 430
esophagus	14%	91.37	208 / 1445	15%	3.42	27 / 183
liver	0%	0	0 / 226	20%	1.57	81 / 406
muscle	15%	81.38	117 / 803	0%	0	0 / 0
skin	5%	34.43	85 / 1809	7%	0.24	31 / 472
blood vessel	7%	54.85	95 / 1335	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0006730	Biological process	one-carbon metabolic process
GO_0015701	Biological process	bicarbonate transport
GO_0031526	Cellular component	brush border membrane
GO_0016324	Cellular component	apical plasma membrane
GO_0030667	Cellular component	secretory granule membrane
GO_0009897	Cellular component	external side of plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0016020	Cellular component	membrane
GO_0070062	Cellular component	extracellular exosome
GO_0005794	Cellular component	Golgi apparatus
GO_0005802	Cellular component	trans-Golgi network
GO_0009986	Cellular component	cell surface
GO_0005793	Cellular component	endoplasmic reticulum-Golgi intermediate compartment
GO_0030658	Cellular component	transport vesicle membrane
GO_0005791	Cellular component	rough endoplasmic reticulum
GO_0016323	Cellular component	basolateral plasma membrane
GO_0004089	Molecular function	carbonate dehydratase activity
GO_0008270	Molecular function	zinc ion binding
GO_0005515	Molecular function	protein binding

Gene name	CA4
Protein name	Carbonic anhydrase 4 (Carbonate dehydratase IV) (Carbonic anhydrase IV) Carbonic anhydrase 4 Carbonic anhydrase 4 (EC 4.2.1.1) (Carbonate dehydratase IV) (Carbonic anhydrase IV) (CA-IV)
Synonyms
Description	FUNCTION: Catalyzes the reversible hydration of carbon dioxide into bicarbonate and protons and thus is essential to maintaining intracellular and extracellular pH . May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis . It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid . .
Accessions	ENST00000300900.9 [P22748-1] ENST00000587265.1 K7EIH9 P22748 ENST00000590203.1 K7EKY5 ENST00000586876.1 [P22748-2] K7ENI8 ENST00000591725.1

CA4 report