CD40 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	34 studies	32% ± 10%	Explore
memory B cell	19 studies	34% ± 8%	Explore
naive B cell	19 studies	36% ± 8%	Explore
endothelial cell	15 studies	26% ± 9%	Explore
dendritic cell	10 studies	32% ± 11%	Explore
endothelial cell of vascular tree	9 studies	22% ± 4%	Explore
capillary endothelial cell	8 studies	21% ± 6%	Explore
conventional dendritic cell	6 studies	25% ± 7%	Explore
plasma cell	6 studies	25% ± 8%	Explore
immature B cell	5 studies	33% ± 8%	Explore
macrophage	4 studies	21% ± 5%	Explore
monocyte	4 studies	23% ± 4%	Explore
fibroblast	4 studies	27% ± 7%	Explore
myeloid cell	4 studies	24% ± 6%	Explore
non-classical monocyte	4 studies	22% ± 5%	Explore
basal cell	4 studies	21% ± 7%	Explore
germinal center B cell	3 studies	52% ± 14%	Explore

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CD40 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
kidney	100%	1335.08	89 / 89	96%	58.30	869 / 901
thymus	100%	1912.81	652 / 653	97%	70.57	584 / 605
lung	100%	3003.03	578 / 578	93%	47.31	1079 / 1155
pancreas	100%	1014.73	328 / 328	93%	40.39	166 / 178
ovary	100%	2124.26	180 / 180	87%	25.06	374 / 430
breast	100%	1848.88	459 / 459	85%	19.79	947 / 1118
uterus	100%	1833.15	170 / 170	83%	38.71	382 / 459
bladder	100%	1770.67	21 / 21	80%	35.41	404 / 504
prostate	100%	2129.56	245 / 245	76%	15.51	381 / 502
adrenal gland	98%	657.43	253 / 258	78%	23.33	179 / 230
stomach	99%	1056.80	357 / 359	76%	21.83	218 / 286
liver	98%	671.41	221 / 226	74%	21.73	302 / 406
skin	100%	1071.82	1803 / 1809	71%	24.42	337 / 472
intestine	99%	1229.04	959 / 966	68%	18.01	356 / 527
esophagus	100%	1209.82	1444 / 1445	66%	16.54	121 / 183
brain	69%	342.08	1836 / 2642	37%	6.33	261 / 705
adipose	100%	2090.25	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	259.46	29 / 29
spleen	100%	3053.10	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	59.61	45 / 45
ureter	0%	0	0 / 0	100%	18.38	1 / 1
blood vessel	100%	1537.61	1330 / 1335	0%	0	0 / 0
heart	99%	855.24	850 / 861	0%	0	0 / 0
muscle	87%	447.17	700 / 803	0%	0	0 / 0
peripheral blood	75%	3358.57	695 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	34%	6.99	27 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0042531	Biological process	positive regulation of tyrosine phosphorylation of STAT protein
GO_0002768	Biological process	immune response-regulating cell surface receptor signaling pathway
GO_0023035	Biological process	CD40 signaling pathway
GO_0006954	Biological process	inflammatory response
GO_0071260	Biological process	cellular response to mechanical stimulus
GO_0043547	Biological process	positive regulation of GTPase activity
GO_0043536	Biological process	positive regulation of blood vessel endothelial cell migration
GO_1901652	Biological process	response to peptide
GO_0045766	Biological process	positive regulation of angiogenesis
GO_0042832	Biological process	defense response to protozoan
GO_0051607	Biological process	defense response to virus
GO_0032735	Biological process	positive regulation of interleukin-12 production
GO_0006874	Biological process	intracellular calcium ion homeostasis
GO_0071347	Biological process	cellular response to interleukin-1
GO_0001934	Biological process	positive regulation of protein phosphorylation
GO_0034341	Biological process	response to type II interferon
GO_0065003	Biological process	protein-containing complex assembly
GO_0030168	Biological process	platelet activation
GO_0043406	Biological process	positive regulation of MAP kinase activity
GO_0051092	Biological process	positive regulation of NF-kappaB transcription factor activity
GO_0071356	Biological process	cellular response to tumor necrosis factor
GO_0033590	Biological process	response to cobalamin
GO_0048304	Biological process	positive regulation of isotype switching to IgG isotypes
GO_0043123	Biological process	positive regulation of canonical NF-kappaB signal transduction
GO_0042113	Biological process	B cell activation
GO_0030890	Biological process	positive regulation of B cell proliferation
GO_0043491	Biological process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0090037	Biological process	positive regulation of protein kinase C signaling
GO_0071222	Biological process	cellular response to lipopolysaccharide
GO_0036018	Biological process	cellular response to erythropoietin
GO_0042100	Biological process	B cell proliferation
GO_0019724	Biological process	B cell mediated immunity
GO_2000353	Biological process	positive regulation of endothelial cell apoptotic process
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0009897	Cellular component	external side of plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0070062	Cellular component	extracellular exosome
GO_0035631	Cellular component	CD40 receptor complex
GO_0043025	Cellular component	neuronal cell body
GO_0009986	Cellular component	cell surface
GO_0043196	Cellular component	varicosity
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0019899	Molecular function	enzyme binding
GO_0038023	Molecular function	signaling receptor activity
GO_0019904	Molecular function	protein domain specific binding
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_0003823	Molecular function	antigen binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	CD40
Protein name	CD40 ligand protein Tumor necrosis factor receptor superfamily member 5 (B-cell surface antigen CD40) (CD40L receptor) Tumor necrosis factor receptor superfamily member 5 (B-cell surface antigen CD40) (Bp50) (CD40L receptor) (CDw40) (CD antigen CD40) CD40 antigen (TNF receptor superfamily member 5), isoform CRA_c (CD40 molecule) CD40 protein CD40 molecule CD40 molecule TNF receptor superfamily member 5 isoform 3
Synonyms	ligand hCG_40016 TNFRSF5
Description	FUNCTION: Receptor for TNFSF5/CD40LG . Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). .
Accessions	Q6P2H9 ENST00000695671.1 ENST00000489304.6 ENST00000620709.4 A0A8Q3SI60 ENST00000466205.5 P25942 ENST00000372276.7 [P25942-2] A0A8Q3WKP3 A0A087X1D0 H0YE23 Q16063 A0A0S2Z349 ENST00000372285.8 [P25942-1] A0A8Q3WKP7 ENST00000477696.6 A0A0S2Z3C7

CD40 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review