Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 26 studies | 32% ± 12% | |
fibroblast | 12 studies | 31% ± 15% | |
endothelial cell of artery | 10 studies | 27% ± 6% | |
endothelial cell of vascular tree | 9 studies | 25% ± 11% | |
vein endothelial cell | 9 studies | 28% ± 10% | |
capillary endothelial cell | 7 studies | 24% ± 6% | |
hepatocyte | 6 studies | 47% ± 21% | |
adventitial cell | 5 studies | 37% ± 3% | |
astrocyte | 5 studies | 32% ± 18% | |
pancreatic D cell | 3 studies | 43% ± 30% | |
microglial cell | 3 studies | 32% ± 17% | |
endocardial cell | 3 studies | 52% ± 9% | |
GABAergic neuron | 3 studies | 41% ± 13% | |
glutamatergic neuron | 3 studies | 47% ± 9% | |
endothelial cell of lymphatic vessel | 3 studies | 18% ± 1% | |
oligodendrocyte precursor cell | 3 studies | 20% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
liver | 100% | 5412.85 | 225 / 226 | 95% | 36.21 | 385 / 406 |
lung | 99% | 3781.66 | 575 / 578 | 91% | 4.61 | 1047 / 1155 |
prostate | 97% | 1610.10 | 237 / 245 | 92% | 4.56 | 462 / 502 |
thymus | 98% | 2890.08 | 637 / 653 | 90% | 6.27 | 544 / 605 |
esophagus | 93% | 1365.04 | 1344 / 1445 | 91% | 4.31 | 166 / 183 |
breast | 99% | 4096.59 | 454 / 459 | 85% | 3.84 | 946 / 1118 |
ovary | 99% | 4136.76 | 179 / 180 | 83% | 2.69 | 359 / 430 |
uterus | 99% | 2776.06 | 169 / 170 | 75% | 2.55 | 346 / 459 |
stomach | 98% | 2424.16 | 352 / 359 | 75% | 2.76 | 214 / 286 |
bladder | 95% | 1286.29 | 20 / 21 | 70% | 2.36 | 354 / 504 |
kidney | 73% | 666.49 | 65 / 89 | 91% | 6.15 | 823 / 901 |
brain | 65% | 546.54 | 1726 / 2642 | 96% | 3.11 | 674 / 705 |
intestine | 82% | 1155.90 | 792 / 966 | 71% | 2.19 | 372 / 527 |
skin | 93% | 1605.51 | 1681 / 1809 | 59% | 1.76 | 280 / 472 |
adrenal gland | 59% | 452.82 | 151 / 258 | 77% | 3.16 | 178 / 230 |
pancreas | 20% | 179.67 | 65 / 328 | 91% | 4.78 | 162 / 178 |
blood vessel | 99% | 2357.94 | 1325 / 1335 | 0% | 0 | 0 / 0 |
adipose | 99% | 3146.55 | 1194 / 1204 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 62% | 1.97 | 28 / 45 |
heart | 56% | 740.39 | 479 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 38% | 0.62 | 11 / 29 |
muscle | 18% | 170.12 | 141 / 803 | 0% | 0 | 0 / 0 |
spleen | 17% | 105.21 | 40 / 241 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 4% | 0.05 | 3 / 80 |
peripheral blood | 1% | 3.64 | 6 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0097009 | Biological process | energy homeostasis |
GO_0019221 | Biological process | cytokine-mediated signaling pathway |
GO_0001525 | Biological process | angiogenesis |
GO_0044321 | Biological process | response to leptin |
GO_0045721 | Biological process | negative regulation of gluconeogenesis |
GO_0046850 | Biological process | regulation of bone remodeling |
GO_0150104 | Biological process | transport across blood-brain barrier |
GO_0005977 | Biological process | glycogen metabolic process |
GO_0008203 | Biological process | cholesterol metabolic process |
GO_0007275 | Biological process | multicellular organism development |
GO_0060259 | Biological process | regulation of feeding behavior |
GO_0001934 | Biological process | positive regulation of protein phosphorylation |
GO_0030217 | Biological process | T cell differentiation |
GO_0033210 | Biological process | leptin-mediated signaling pathway |
GO_0006094 | Biological process | gluconeogenesis |
GO_0098868 | Biological process | bone growth |
GO_0051049 | Biological process | regulation of transport |
GO_0019953 | Biological process | sexual reproduction |
GO_0006909 | Biological process | phagocytosis |
GO_0120162 | Biological process | positive regulation of cold-induced thermogenesis |
GO_0010507 | Biological process | negative regulation of autophagy |
GO_0006112 | Biological process | energy reserve metabolic process |
GO_0014009 | Biological process | glial cell proliferation |
GO_0042593 | Biological process | glucose homeostasis |
GO_0007166 | Biological process | cell surface receptor signaling pathway |
GO_0009897 | Cellular component | external side of plasma membrane |
GO_0043235 | Cellular component | receptor complex |
GO_0005576 | Cellular component | extracellular region |
GO_0016323 | Cellular component | basolateral plasma membrane |
GO_0004888 | Molecular function | transmembrane signaling receptor activity |
GO_0038021 | Molecular function | leptin receptor activity |
GO_0019955 | Molecular function | cytokine binding |
GO_0004896 | Molecular function | cytokine receptor activity |
GO_0005515 | Molecular function | protein binding |
Gene name | LEPR |
Protein name | Leptin receptor (LEP-R) (HuB219) (OB receptor) (OB-R) (CD antigen CD295) LEPR protein Leptin receptor LEPR protein ( OBR,CD295protein ) (Leptin receptor) |
Synonyms | OBR,CD295 DB OBR |
Description | FUNCTION: Receptor for hormone LEP/leptin (Probable) . On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (By similarity) . In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity . Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus. Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T -ells. Leptin increases Th1 and suppresses Th2 cytokine production (By similarity). .; FUNCTION: [Isoform A]: May transport LEP across the blood-brain barrier. Binds LEP and mediates LEP endocytosis. Does not induce phosphorylation of and activate STAT3. .; FUNCTION: [Isoform E]: Antagonizes Isoform A and isoform B-mediated LEP binding and endocytosis. . |
Accessions | A0A387LAQ1 ENST00000349533.11 [P48357-1] A0A2Z6I6G4 ENST00000344610.12 [P48357-4] A0A387LAM3 A0A387LAK6 A0A387LBM8 ENST00000371060.7 [P48357-2] A0A2Z6IBQ7 A0A0U3T571 A0A387LBR5 A0A387LAL5 ENST00000371058.1 [P48357-4] A0A387LAW1 A0A387LC27 ENST00000616738.4 [P48357-2] A2RRQ4 A0A387LBH1 A0A387LBG4 A0A387LC10 A0A387LBZ8 ENST00000371059.7 [P48357-3] A0A4P8P008 P48357 A0A387LAN4 Q4G138 A0A387LBY6 A0A387LBE6 A0A387LAQ4 |