LEPR report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097009Biological processenergy homeostasis
GO_0019221Biological processcytokine-mediated signaling pathway
GO_0001525Biological processangiogenesis
GO_0044321Biological processresponse to leptin
GO_0045721Biological processnegative regulation of gluconeogenesis
GO_0046850Biological processregulation of bone remodeling
GO_0150104Biological processtransport across blood-brain barrier
GO_0005977Biological processglycogen metabolic process
GO_0008203Biological processcholesterol metabolic process
GO_0007275Biological processmulticellular organism development
GO_0060259Biological processregulation of feeding behavior
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0030217Biological processT cell differentiation
GO_0033210Biological processleptin-mediated signaling pathway
GO_0006094Biological processgluconeogenesis
GO_0098868Biological processbone growth
GO_0051049Biological processregulation of transport
GO_0019953Biological processsexual reproduction
GO_0006909Biological processphagocytosis
GO_0120162Biological processpositive regulation of cold-induced thermogenesis
GO_0010507Biological processnegative regulation of autophagy
GO_0006112Biological processenergy reserve metabolic process
GO_0014009Biological processglial cell proliferation
GO_0042593Biological processglucose homeostasis
GO_0007166Biological processcell surface receptor signaling pathway
GO_0009897Cellular componentexternal side of plasma membrane
GO_0043235Cellular componentreceptor complex
GO_0005576Cellular componentextracellular region
GO_0016323Cellular componentbasolateral plasma membrane
GO_0004888Molecular functiontransmembrane signaling receptor activity
GO_0038021Molecular functionleptin receptor activity
GO_0019955Molecular functioncytokine binding
GO_0004896Molecular functioncytokine receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLEPR
Protein nameLeptin receptor (LEP-R) (HuB219) (OB receptor) (OB-R) (CD antigen CD295)
LEPR protein
Leptin receptor
LEPR protein ( OBR,CD295protein ) (Leptin receptor)
SynonymsOBR,CD295
DB
OBR
DescriptionFUNCTION: Receptor for hormone LEP/leptin (Probable) . On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (By similarity) . In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity . Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus. Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T -ells. Leptin increases Th1 and suppresses Th2 cytokine production (By similarity). .; FUNCTION: [Isoform A]: May transport LEP across the blood-brain barrier. Binds LEP and mediates LEP endocytosis. Does not induce phosphorylation of and activate STAT3. .; FUNCTION: [Isoform E]: Antagonizes Isoform A and isoform B-mediated LEP binding and endocytosis. .

AccessionsA0A387LAQ1
ENST00000349533.11 [P48357-1]
A0A2Z6I6G4
ENST00000344610.12 [P48357-4]
A0A387LAM3
A0A387LAK6
A0A387LBM8
ENST00000371060.7 [P48357-2]
A0A2Z6IBQ7
A0A0U3T571
A0A387LBR5
A0A387LAL5
ENST00000371058.1 [P48357-4]
A0A387LAW1
A0A387LC27
ENST00000616738.4 [P48357-2]
A2RRQ4
A0A387LBH1
A0A387LBG4
A0A387LC10
A0A387LBZ8
ENST00000371059.7 [P48357-3]
A0A4P8P008
P48357
A0A387LAN4
Q4G138
A0A387LBY6
A0A387LBE6
A0A387LAQ4