I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| plasmacytoid dendritic cell | 6 studies | 26% ± 11% | |
| classical monocyte | 5 studies | 20% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| plasmacytoid dendritic cell | 6 studies | 26% ± 11% | |
| classical monocyte | 5 studies | 20% ± 3% |
Insufficient scRNA-seq data for expression of CCR2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 98% | 515.55 | 568 / 578 | 83% | 5.06 | 955 / 1155 |
| thymus | 81% | 141.64 | 526 / 653 | 78% | 3.33 | 472 / 605 |
| stomach | 84% | 149.74 | 303 / 359 | 57% | 1.89 | 164 / 286 |
| prostate | 81% | 137.18 | 199 / 245 | 60% | 1.72 | 302 / 502 |
| kidney | 56% | 119.10 | 50 / 89 | 82% | 5.97 | 735 / 901 |
| intestine | 89% | 266.89 | 855 / 966 | 48% | 2.01 | 253 / 527 |
| breast | 53% | 65.12 | 241 / 459 | 81% | 5.04 | 903 / 1118 |
| bladder | 76% | 151.43 | 16 / 21 | 48% | 1.77 | 244 / 504 |
| uterus | 71% | 79.98 | 120 / 170 | 50% | 1.69 | 228 / 459 |
| pancreas | 45% | 55.90 | 146 / 328 | 74% | 3.47 | 131 / 178 |
| skin | 40% | 43.01 | 727 / 1809 | 66% | 4.26 | 310 / 472 |
| spleen | 100% | 2212.94 | 241 / 241 | 0% | 0 | 0 / 0 |
| liver | 55% | 55.68 | 125 / 226 | 42% | 1.23 | 170 / 406 |
| esophagus | 67% | 81.93 | 970 / 1445 | 27% | 0.79 | 50 / 183 |
| lymph node | 0% | 0 | 0 / 0 | 93% | 6.92 | 27 / 29 |
| peripheral blood | 87% | 2155.37 | 804 / 929 | 0% | 0 | 0 / 0 |
| adipose | 83% | 143.68 | 1000 / 1204 | 0% | 0 | 0 / 0 |
| adrenal gland | 60% | 59.34 | 155 / 258 | 14% | 0.25 | 33 / 230 |
| blood vessel | 69% | 119.83 | 923 / 1335 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 67% | 3.41 | 30 / 45 |
| ovary | 27% | 26.51 | 49 / 180 | 38% | 1.19 | 163 / 430 |
| heart | 41% | 40.63 | 349 / 861 | 0% | 0 | 0 / 0 |
| brain | 3% | 2.00 | 79 / 2642 | 19% | 0.62 | 134 / 705 |
| eye | 0% | 0 | 0 / 0 | 8% | 0.42 | 6 / 80 |
| muscle | 5% | 3.00 | 39 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0002407 | Biological process | dendritic cell chemotaxis |
| GO_0019233 | Biological process | sensory perception of pain |
| GO_0007194 | Biological process | negative regulation of adenylate cyclase activity |
| GO_0019221 | Biological process | cytokine-mediated signaling pathway |
| GO_0050870 | Biological process | positive regulation of T cell activation |
| GO_0090594 | Biological process | inflammatory response to wounding |
| GO_0001974 | Biological process | blood vessel remodeling |
| GO_0006954 | Biological process | inflammatory response |
| GO_0030097 | Biological process | hemopoiesis |
| GO_0045580 | Biological process | regulation of T cell differentiation |
| GO_2000451 | Biological process | positive regulation of CD8-positive, alpha-beta T cell extravasation |
| GO_0019722 | Biological process | calcium-mediated signaling |
| GO_1904783 | Biological process | positive regulation of NMDA glutamate receptor activity |
| GO_2000473 | Biological process | positive regulation of hematopoietic stem cell migration |
| GO_0010820 | Biological process | positive regulation of T cell chemotaxis |
| GO_0090026 | Biological process | positive regulation of monocyte chemotaxis |
| GO_2000464 | Biological process | positive regulation of astrocyte chemotaxis |
| GO_0006935 | Biological process | chemotaxis |
| GO_0006874 | Biological process | intracellular calcium ion homeostasis |
| GO_0090265 | Biological process | positive regulation of immune complex clearance by monocytes and macrophages |
| GO_0006968 | Biological process | cellular defense response |
| GO_0050727 | Biological process | regulation of inflammatory response |
| GO_0002829 | Biological process | negative regulation of type 2 immune response |
| GO_0019725 | Biological process | cellular homeostasis |
| GO_0048873 | Biological process | homeostasis of number of cells within a tissue |
| GO_0006959 | Biological process | humoral immune response |
| GO_0016525 | Biological process | negative regulation of angiogenesis |
| GO_0032743 | Biological process | positive regulation of interleukin-2 production |
| GO_0006955 | Biological process | immune response |
| GO_1903238 | Biological process | positive regulation of leukocyte tethering or rolling |
| GO_2000439 | Biological process | positive regulation of monocyte extravasation |
| GO_0070098 | Biological process | chemokine-mediated signaling pathway |
| GO_0007204 | Biological process | positive regulation of cytosolic calcium ion concentration |
| GO_0097350 | Biological process | neutrophil clearance |
| GO_0010574 | Biological process | regulation of vascular endothelial growth factor production |
| GO_0046641 | Biological process | positive regulation of alpha-beta T cell proliferation |
| GO_1905517 | Biological process | macrophage migration |
| GO_0120162 | Biological process | positive regulation of cold-induced thermogenesis |
| GO_0002724 | Biological process | regulation of T cell cytokine production |
| GO_1905521 | Biological process | regulation of macrophage migration |
| GO_0061756 | Biological process | leukocyte adhesion to vascular endothelial cell |
| GO_0051968 | Biological process | positive regulation of synaptic transmission, glutamatergic |
| GO_0032729 | Biological process | positive regulation of type II interferon production |
| GO_2000412 | Biological process | positive regulation of thymocyte migration |
| GO_0050729 | Biological process | positive regulation of inflammatory response |
| GO_0002827 | Biological process | positive regulation of T-helper 1 type immune response |
| GO_0002548 | Biological process | monocyte chemotaxis |
| GO_0043310 | Biological process | negative regulation of eosinophil degranulation |
| GO_0009611 | Biological process | response to wounding |
| GO_0032760 | Biological process | positive regulation of tumor necrosis factor production |
| GO_0007259 | Biological process | cell surface receptor signaling pathway via JAK-STAT |
| GO_0060326 | Biological process | cell chemotaxis |
| GO_0035705 | Biological process | T-helper 17 cell chemotaxis |
| GO_0035696 | Biological process | monocyte extravasation |
| GO_0009897 | Cellular component | external side of plasma membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0016020 | Cellular component | membrane |
| GO_0043204 | Cellular component | perikaryon |
| GO_0043025 | Cellular component | neuronal cell body |
| GO_0001650 | Cellular component | fibrillar center |
| GO_0030425 | Cellular component | dendrite |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0035715 | Molecular function | chemokine (C-C motif) ligand 2 binding |
| GO_0035717 | Molecular function | chemokine (C-C motif) ligand 7 binding |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0031727 | Molecular function | CCR2 chemokine receptor binding |
| GO_0016493 | Molecular function | C-C chemokine receptor activity |
| GO_0035716 | Molecular function | chemokine (C-C motif) ligand 12 binding |
| GO_0004950 | Molecular function | chemokine receptor activity |
| GO_0019957 | Molecular function | C-C chemokine binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | CCR2 |
| Protein name | C-C chemokine receptor type 2 Chemokine receptor 2 C-C motif chemokine receptor 2 C-C chemokine receptor type 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (Monocyte chemoattractant protein 1 receptor) (MCP-1-R) (CD antigen CD192) |
| Synonyms | CMKBR2 |
| Description | FUNCTION: Key functional receptor for CCL2 but can also bind CCL7 and CCL12 . Its binding with CCL2 on monocytes and macrophages mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (Probable). Also acts as a receptor for the beta-defensin DEFB106A/DEFB106B . Regulates the expression of T-cell inflammatory cytokines and T-cell differentiation, promoting the differentiation of T-cells into T-helper 17 cells (Th17) during inflammation (By similarity). Facilitates the export of mature thymocytes by enhancing directional movement of thymocytes to sphingosine-1-phosphate stimulation and up-regulation of S1P1R expression; signals through the JAK-STAT pathway to regulate FOXO1 activity leading to an increased expression of S1P1R (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By similarity). Mediates the recruitment of macrophages and monocytes to the injury site following brain injury (By similarity). .; FUNCTION: (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection. . |
| Accessions | ENST00000445132.3 [P41597-2] E9PH76 B4XH69 ENST00000421659.1 L7RER4 P41597 B4XH68 L7REX9 ENST00000400888.2 [P41597-1] |
