VTCN1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of VTCN1 at tissue level.

III. Associated gene sets

GO_0002250Biological processadaptive immune response
GO_0042102Biological processpositive regulation of T cell proliferation
GO_0001562Biological processresponse to protozoan
GO_0050868Biological processnegative regulation of T cell activation
GO_0043066Biological processnegative regulation of apoptotic process
GO_0042130Biological processnegative regulation of T cell proliferation
GO_0050852Biological processT cell receptor signaling pathway
GO_0001817Biological processregulation of cytokine production
GO_0032743Biological processpositive regulation of interleukin-2 production
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005102Molecular functionsignaling receptor binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameVTCN1
Protein nameV-set domain containing T cell activation inhibitor 1
V-set domain-containing T-cell activation inhibitor 1 (B7 homolog 4) (B7-H4) (B7h.5) (Immune costimulatory protein B7-H4) (Protein B7S1) (T-cell costimulatory molecule B7x)
SynonymsUNQ659/PRO1291
B7H4
DescriptionFUNCTION: Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation. .

AccessionsENST00000328189.7 [Q7Z7D3-2]
ENST00000369458.8 [Q7Z7D3-1]
Q5T2L0
Q7Z7D3
ENST00000359008.8
ENST00000539893.5 [Q7Z7D3-4]