IL27RA | OmnibusX

Name	Number of supported studies	Average coverage
natural killer cell	22 studies	21% ± 7%	Explore
CD4-positive, alpha-beta T cell	17 studies	25% ± 11%	Explore
regulatory T cell	15 studies	24% ± 8%	Explore
CD8-positive, alpha-beta T cell	14 studies	23% ± 10%	Explore
T cell	12 studies	20% ± 5%	Explore
gamma-delta T cell	9 studies	21% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	8 studies	24% ± 10%	Explore
CD16-negative, CD56-bright natural killer cell, human	7 studies	24% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	7 studies	20% ± 5%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	22% ± 7%	Explore
classical monocyte	6 studies	23% ± 6%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	6 studies	20% ± 5%	Explore
mucosal invariant T cell	6 studies	18% ± 2%	Explore
B cell	6 studies	19% ± 4%	Explore
mature NK T cell	5 studies	25% ± 8%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	21% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	22% ± 5%	Explore
T follicular helper cell	4 studies	18% ± 3%	Explore
innate lymphoid cell	4 studies	18% ± 2%	Explore
conventional dendritic cell	3 studies	27% ± 6%	Explore
exhausted T cell	3 studies	23% ± 8%	Explore
dendritic cell	3 studies	31% ± 9%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	26% ± 5%	Explore

Name	Number of supported studies	Average coverage
peripheral blood	7 studies	20% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	629.61	651 / 653	98%	29.19	593 / 605
lung	100%	1216.72	578 / 578	97%	34.33	1126 / 1155
breast	100%	980.12	459 / 459	94%	29.13	1054 / 1118
uterus	99%	417.31	168 / 170	92%	26.35	423 / 459
intestine	96%	525.37	929 / 966	94%	18.09	495 / 527
stomach	96%	309.99	345 / 359	94%	18.81	268 / 286
kidney	100%	512.45	89 / 89	89%	19.39	803 / 901
esophagus	96%	335.04	1394 / 1445	92%	25.00	169 / 183
bladder	100%	413.38	21 / 21	81%	18.46	410 / 504
skin	91%	313.05	1639 / 1809	85%	30.91	402 / 472
pancreas	81%	219.34	267 / 328	93%	18.00	165 / 178
prostate	99%	540.94	242 / 245	75%	8.00	377 / 502
brain	91%	278.73	2401 / 2642	71%	7.27	498 / 705
ovary	53%	118.63	95 / 180	86%	20.20	368 / 430
adrenal gland	92%	228.39	238 / 258	44%	4.36	102 / 230
lymph node	0%	0	0 / 0	100%	53.18	29 / 29
spleen	100%	2070.03	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	58.54	45 / 45
peripheral blood	100%	1829.87	928 / 929	0%	0	0 / 0
adipose	100%	890.10	1202 / 1204	0%	0	0 / 0
heart	99%	461.59	849 / 861	0%	0	0 / 0
liver	38%	76.55	87 / 226	52%	7.02	211 / 406
blood vessel	75%	249.77	1001 / 1335	0%	0	0 / 0
muscle	73%	145.49	584 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	13%	0.92	10 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0019221	Biological process	cytokine-mediated signaling pathway
GO_2000317	Biological process	negative regulation of T-helper 17 type immune response
GO_0032715	Biological process	negative regulation of interleukin-6 production
GO_0002829	Biological process	negative regulation of type 2 immune response
GO_0006955	Biological process	immune response
GO_0050830	Biological process	defense response to Gram-positive bacterium
GO_2000408	Biological process	negative regulation of T cell extravasation
GO_0032729	Biological process	positive regulation of type II interferon production
GO_0002827	Biological process	positive regulation of T-helper 1 type immune response
GO_0032700	Biological process	negative regulation of interleukin-17 production
GO_0048302	Biological process	regulation of isotype switching to IgG isotypes
GO_0032720	Biological process	negative regulation of tumor necrosis factor production
GO_0043524	Biological process	negative regulation of neuron apoptotic process
GO_0070106	Biological process	interleukin-27-mediated signaling pathway
GO_0007166	Biological process	cell surface receptor signaling pathway
GO_0009897	Cellular component	external side of plasma membrane
GO_0043235	Cellular component	receptor complex
GO_0005886	Cellular component	plasma membrane
GO_0004888	Molecular function	transmembrane signaling receptor activity
GO_0019955	Molecular function	cytokine binding
GO_0045509	Molecular function	interleukin-27 receptor activity
GO_0005515	Molecular function	protein binding

Gene name	IL27RA
Protein name	Interleukin-27 receptor subunit alpha (IL-27 receptor subunit alpha) (IL-27R subunit alpha) (IL-27R-alpha) (IL-27RA) (Cytokine receptor WSX-1) (Cytokine receptor-like 1) (Type I T-cell cytokine receptor) (TCCR) (ZcytoR1)
Synonyms	CRL1 WSX1 TCCR UNQ296/PRO336
Description	FUNCTION: Receptor for IL27. Requires IL6ST/GP130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL6ST/GP130 and CNTFR . Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms. .
Accessions	ENST00000263379.4 Q6UWB1 ENST00000672064.1

IL27RA report