I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell of lymphatic vessel | 3 studies | 24% ± 2% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell of lymphatic vessel | 3 studies | 24% ± 2% |
Insufficient scRNA-seq data for expression of ACKR2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 615.41 | 226 / 226 | 78% | 4.38 | 316 / 406 |
| breast | 98% | 330.97 | 448 / 459 | 54% | 3.00 | 599 / 1118 |
| esophagus | 98% | 215.46 | 1418 / 1445 | 40% | 1.17 | 73 / 183 |
| lung | 98% | 176.82 | 565 / 578 | 36% | 2.17 | 416 / 1155 |
| bladder | 90% | 196.90 | 19 / 21 | 39% | 5.28 | 197 / 504 |
| thymus | 99% | 361.40 | 647 / 653 | 16% | 0.27 | 96 / 605 |
| uterus | 64% | 69.77 | 108 / 170 | 42% | 3.51 | 194 / 459 |
| intestine | 85% | 125.57 | 819 / 966 | 18% | 0.38 | 96 / 527 |
| adipose | 99% | 563.12 | 1196 / 1204 | 0% | 0 | 0 / 0 |
| prostate | 72% | 66.92 | 176 / 245 | 23% | 0.63 | 116 / 502 |
| stomach | 73% | 79.92 | 263 / 359 | 22% | 0.50 | 62 / 286 |
| adrenal gland | 91% | 97.42 | 234 / 258 | 2% | 0.03 | 5 / 230 |
| ovary | 22% | 23.54 | 40 / 180 | 69% | 6.49 | 297 / 430 |
| blood vessel | 90% | 196.79 | 1195 / 1335 | 0% | 0 | 0 / 0 |
| skin | 73% | 157.52 | 1318 / 1809 | 11% | 0.22 | 51 / 472 |
| pancreas | 30% | 19.71 | 99 / 328 | 52% | 1.90 | 93 / 178 |
| kidney | 62% | 71.04 | 55 / 89 | 19% | 0.42 | 173 / 901 |
| spleen | 65% | 56.32 | 156 / 241 | 0% | 0 | 0 / 0 |
| brain | 29% | 20.25 | 754 / 2642 | 21% | 0.31 | 151 / 705 |
| heart | 47% | 64.70 | 408 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 29% | 0.53 | 13 / 45 |
| muscle | 26% | 24.56 | 209 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 4% | 3.02 | 37 / 929 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.04 | 1 / 29 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0006954 | Biological process | inflammatory response |
| GO_0019722 | Biological process | calcium-mediated signaling |
| GO_0006955 | Biological process | immune response |
| GO_0016192 | Biological process | vesicle-mediated transport |
| GO_0035556 | Biological process | intracellular signal transduction |
| GO_0070098 | Biological process | chemokine-mediated signaling pathway |
| GO_0007204 | Biological process | positive regulation of cytosolic calcium ion concentration |
| GO_0060326 | Biological process | cell chemotaxis |
| GO_0009897 | Cellular component | external side of plasma membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0055037 | Cellular component | recycling endosome |
| GO_0005769 | Cellular component | early endosome |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005884 | Cellular component | actin filament |
| GO_0005829 | Cellular component | cytosol |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0031965 | Cellular component | nuclear membrane |
| GO_0005044 | Molecular function | scavenger receptor activity |
| GO_0016493 | Molecular function | C-C chemokine receptor activity |
| GO_0004950 | Molecular function | chemokine receptor activity |
| GO_0019957 | Molecular function | C-C chemokine binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | ACKR2 |
| Protein name | Atypical chemokine receptor 2 Atypical chemokine receptor 2 (C-C chemokine receptor D6) (Chemokine receptor CCR-10) (Chemokine receptor CCR-9) (Chemokine-binding protein 2) (Chemokine-binding protein D6) |
| Synonyms | D6 CMKBR9 CCBP2 CCR10 |
| Description | FUNCTION: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Upon active ligand stimulation, activates a beta-arrestin 1 (ARRB1)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. By scavenging chemokines in tissues, on the surfaces of lymphatic vessels, and in placenta, plays an essential role in the resolution (termination) of the inflammatory response and in the regulation of adaptive immune responses. Plays a major role in the immune silencing of macrophages during the resolution of inflammation. Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells (LECs) and is required for immature/mature dendritic cells discrimination by LECs. . |
| Accessions | ENST00000497921.2 ENST00000492609.1 V9GYB7 O00590 ENST00000442925.5 ENST00000493193.1 ENST00000422265.6 V9GYX0 V9GYM0 V9GZ70 ENST00000494619.1 |
