I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| retina horizontal cell | 6 studies | 60% ± 14% | |
| cardiac muscle cell | 5 studies | 31% ± 4% | |
| retinal ganglion cell | 4 studies | 47% ± 25% | |
| GABAergic neuron | 3 studies | 34% ± 12% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| retina horizontal cell | 6 studies | 60% ± 14% | |
| cardiac muscle cell | 5 studies | 31% ± 4% | |
| retinal ganglion cell | 4 studies | 47% ± 25% | |
| GABAergic neuron | 3 studies | 34% ± 12% |
Insufficient scRNA-seq data for expression of SLC4A3 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 95% | 6907.00 | 2514 / 2642 | 99% | 34.42 | 697 / 705 |
| ovary | 100% | 28032.21 | 180 / 180 | 94% | 15.40 | 404 / 430 |
| adrenal gland | 99% | 3506.56 | 256 / 258 | 92% | 29.06 | 212 / 230 |
| prostate | 93% | 2370.96 | 227 / 245 | 98% | 12.05 | 494 / 502 |
| uterus | 97% | 3436.01 | 165 / 170 | 62% | 7.72 | 285 / 459 |
| breast | 47% | 732.16 | 214 / 459 | 85% | 8.94 | 954 / 1118 |
| esophagus | 62% | 1747.58 | 898 / 1445 | 66% | 7.72 | 120 / 183 |
| heart | 99% | 30576.97 | 854 / 861 | 0% | 0 | 0 / 0 |
| pancreas | 7% | 95.90 | 22 / 328 | 85% | 8.03 | 152 / 178 |
| eye | 0% | 0 | 0 / 0 | 84% | 10.96 | 67 / 80 |
| skin | 5% | 72.61 | 92 / 1809 | 76% | 11.09 | 357 / 472 |
| kidney | 39% | 619.38 | 35 / 89 | 41% | 3.73 | 371 / 901 |
| bladder | 14% | 143.48 | 3 / 21 | 59% | 6.41 | 296 / 504 |
| lung | 3% | 60.18 | 15 / 578 | 65% | 7.25 | 745 / 1155 |
| thymus | 15% | 181.34 | 95 / 653 | 49% | 3.33 | 296 / 605 |
| tonsil | 0% | 0 | 0 / 0 | 47% | 3.50 | 21 / 45 |
| stomach | 18% | 244.84 | 65 / 359 | 26% | 2.18 | 75 / 286 |
| intestine | 11% | 126.34 | 105 / 966 | 25% | 1.94 | 133 / 527 |
| adipose | 32% | 563.88 | 387 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 24% | 321.58 | 57 / 241 | 0% | 0 | 0 / 0 |
| liver | 0% | 0 | 0 / 226 | 18% | 5.40 | 72 / 406 |
| blood vessel | 17% | 290.66 | 224 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 0% | 3.59 | 2 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0051453 | Biological process | regulation of intracellular pH |
| GO_0098901 | Biological process | regulation of cardiac muscle cell action potential |
| GO_0015701 | Biological process | bicarbonate transport |
| GO_1902476 | Biological process | chloride transmembrane transport |
| GO_0045851 | Biological process | pH reduction |
| GO_0086001 | Biological process | cardiac muscle cell action potential |
| GO_0061337 | Biological process | cardiac conduction |
| GO_0055085 | Biological process | transmembrane transport |
| GO_0150104 | Biological process | transport across blood-brain barrier |
| GO_0009897 | Cellular component | external side of plasma membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0140900 | Molecular function | chloride:bicarbonate antiporter activity |
| GO_0015106 | Molecular function | bicarbonate transmembrane transporter activity |
| GO_0005452 | Molecular function | solute:inorganic anion antiporter activity |
| GO_0022857 | Molecular function | transmembrane transporter activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | SLC4A3 |
| Protein name | Anion exchange protein 3 (AE 3) (Anion exchanger 3) (CAE3/BAE3) (Cardiac/brain band 3-like protein) (Neuronal band 3-like protein) (Solute carrier family 4 member 3) Solute carrier family 4 member 3 |
| Synonyms | AE3 |
| Description | FUNCTION: Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane . May be involved in the regulation of intracellular pH, and the modulation of cardiac action potential . . |
| Accessions | ENST00000358055.8 [P48751-1] ENST00000273063.10 [P48751-3] F8WD49 ENST00000373760.6 [P48751-1] P48751 H7C160 ENST00000317151.7 [P48751-1] ENST00000444906.1 H7C1Z2 ENST00000425141.5 E9PCP1 ENST00000413743.5 ENST00000416910.1 |
