CD8A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007169Biological processcell surface receptor protein tyrosine kinase signaling pathway
GO_0050852Biological processT cell receptor signaling pathway
GO_0006955Biological processimmune response
GO_0002250Biological processadaptive immune response
GO_0019882Biological processantigen processing and presentation
GO_0002456Biological processT cell mediated immunity
GO_0042110Biological processT cell activation
GO_0007166Biological processcell surface receptor signaling pathway
GO_0045065Biological processcytotoxic T cell differentiation
GO_0009897Cellular componentexternal side of plasma membrane
GO_0043235Cellular componentreceptor complex
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0044853Cellular componentplasma membrane raft
GO_0042101Cellular componentT cell receptor complex
GO_0015026Molecular functioncoreceptor activity
GO_0023024Molecular functionMHC class I protein complex binding
GO_0042288Molecular functionMHC class I protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCD8A
Protein nameT-cell surface glycoprotein CD8 alpha chain
T-cell surface glycoprotein CD8 alpha chain (T-lymphocyte differentiation antigen T8/Leu-2) (CD antigen CD8a)
SynonymshCG_34192
MAL
DescriptionFUNCTION: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells. .

AccessionsP01732
ENST00000409781.1
ENST00000699439.1 [P01732-2]
Q8TAW8
B8ZZZ4
ENST00000283635.8 [P01732-1]
ENST00000352580.7 [P01732-2]
Q96QR6
ENST00000409511.6 [P01732-1]