I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| group 3 innate lymphoid cell | 3 studies | 30% ± 5% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| group 3 innate lymphoid cell | 3 studies | 30% ± 5% |
Insufficient scRNA-seq data for expression of IL23R at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| adrenal gland | 98% | 51.84 | 254 / 258 | 5% | 0.21 | 11 / 230 |
| intestine | 49% | 14.06 | 474 / 966 | 28% | 0.50 | 145 / 527 |
| spleen | 53% | 8.02 | 128 / 241 | 0% | 0 | 0 / 0 |
| lung | 46% | 6.76 | 264 / 578 | 2% | 0.04 | 27 / 1155 |
| bladder | 33% | 3.10 | 7 / 21 | 10% | 0.21 | 51 / 504 |
| stomach | 17% | 1.54 | 61 / 359 | 23% | 0.44 | 66 / 286 |
| peripheral blood | 40% | 68.89 | 371 / 929 | 0% | 0 | 0 / 0 |
| pancreas | 25% | 2.17 | 82 / 328 | 3% | 0.04 | 6 / 178 |
| liver | 22% | 1.98 | 50 / 226 | 1% | 0.02 | 3 / 406 |
| prostate | 20% | 2.10 | 48 / 245 | 0% | 0.00 | 2 / 502 |
| esophagus | 12% | 1.18 | 178 / 1445 | 4% | 0.06 | 7 / 183 |
| kidney | 13% | 2.10 | 12 / 89 | 1% | 0.03 | 9 / 901 |
| adipose | 14% | 1.39 | 173 / 1204 | 0% | 0 | 0 / 0 |
| breast | 11% | 1.14 | 51 / 459 | 0% | 0.01 | 5 / 1118 |
| thymus | 11% | 1.09 | 75 / 653 | 0% | 0 | 0 / 605 |
| lymph node | 0% | 0 | 0 / 0 | 10% | 0.85 | 3 / 29 |
| uterus | 5% | 0.32 | 9 / 170 | 0% | 0.01 | 1 / 459 |
| ovary | 4% | 0.28 | 8 / 180 | 0% | 0.02 | 1 / 430 |
| skin | 3% | 0.24 | 55 / 1809 | 1% | 0.03 | 7 / 472 |
| blood vessel | 4% | 0.47 | 51 / 1335 | 0% | 0 | 0 / 0 |
| heart | 2% | 0.15 | 17 / 861 | 0% | 0 | 0 / 0 |
| muscle | 2% | 0.19 | 15 / 803 | 0% | 0 | 0 / 0 |
| brain | 1% | 0.10 | 25 / 2642 | 0% | 0.00 | 1 / 705 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0042531 | Biological process | positive regulation of tyrosine phosphorylation of STAT protein |
| GO_0019221 | Biological process | cytokine-mediated signaling pathway |
| GO_0042102 | Biological process | positive regulation of T cell proliferation |
| GO_0042104 | Biological process | positive regulation of activated T cell proliferation |
| GO_0051135 | Biological process | positive regulation of NK T cell activation |
| GO_0010536 | Biological process | positive regulation of activation of Janus kinase activity |
| GO_0006954 | Biological process | inflammatory response |
| GO_0043382 | Biological process | positive regulation of memory T cell differentiation |
| GO_2000318 | Biological process | positive regulation of T-helper 17 type immune response |
| GO_0032819 | Biological process | positive regulation of natural killer cell proliferation |
| GO_0050829 | Biological process | defense response to Gram-negative bacterium |
| GO_0032735 | Biological process | positive regulation of interleukin-12 production |
| GO_0034341 | Biological process | response to type II interferon |
| GO_0032693 | Biological process | negative regulation of interleukin-10 production |
| GO_0001916 | Biological process | positive regulation of T cell mediated cytotoxicity |
| GO_0038155 | Biological process | interleukin-23-mediated signaling pathway |
| GO_0045672 | Biological process | positive regulation of osteoclast differentiation |
| GO_0032725 | Biological process | positive regulation of granulocyte macrophage colony-stimulating factor production |
| GO_0032729 | Biological process | positive regulation of type II interferon production |
| GO_0002827 | Biological process | positive regulation of T-helper 1 type immune response |
| GO_2000330 | Biological process | positive regulation of T-helper 17 cell lineage commitment |
| GO_0002230 | Biological process | positive regulation of defense response to virus by host |
| GO_0042509 | Biological process | regulation of tyrosine phosphorylation of STAT protein |
| GO_0032740 | Biological process | positive regulation of interleukin-17 production |
| GO_0032496 | Biological process | response to lipopolysaccharide |
| GO_0072536 | Cellular component | interleukin-23 receptor complex |
| GO_0009897 | Cellular component | external side of plasma membrane |
| GO_0043235 | Cellular component | receptor complex |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0042019 | Molecular function | interleukin-23 binding |
| GO_0042020 | Molecular function | interleukin-23 receptor activity |
| GO_0019955 | Molecular function | cytokine binding |
| GO_0004896 | Molecular function | cytokine receptor activity |
| GO_0005143 | Molecular function | interleukin-12 receptor binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | IL23R |
| Protein name | Interleukin-23 receptor (IL-23 receptor) (IL-23R) Interleukin 23 receptor |
| Synonyms | |
| Description | FUNCTION: Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. . |
| Accessions | A0A8V8TL70 ENST00000697227.1 ENST00000697158.1 Q5VWK5 A0A8V8TL76 ENST00000697226.1 B6VNT4 B6HY67 A0A8V8TM22 B6VNT7 ENST00000425614.3 [Q5VWK5-6] ENST00000697224.1 [Q5VWK5-4] ENST00000347310.10 [Q5VWK5-1] D9N2T9 B6HY73 B6HY76 ENST00000697152.1 B6HY85 ENST00000697151.1 [Q5VWK5-3] B6HY89 ENST00000697148.1 A0A8V8TM95 A0A8V8TKQ8 A0A8V8TKS9 A0A8V8TL38 ENST00000697162.1 ENST00000697232.1 B6HY86 A0A8V8TKR3 B6HY75 ENST00000697230.1 ENST00000697228.1 A0A0D9SFJ7 A0A8V8TL42 ENST00000697160.1 B6HY77 B6HY79 A0A8V8TM17 B6HY68 B6HY69 ENST00000697222.1 ENST00000697163.1 ENST00000697157.1 ENST00000697154.1 A0A8V8TMD5 A0A8V8TKV7 ENST00000697159.1 B6HY74 A0A8V8TKQ4 B6VNT5 ENST00000697161.1 A0A8V8TME0 ENST00000697231.1 ENST00000473881.2 ENST00000697149.1 [Q5VWK5-4] A0A8V8TKS2 ENST00000697229.1 ENST00000697156.1 ENST00000697223.1 [Q5VWK5-4] B6VNT6 ENST00000697153.1 [Q5VWK5-4] B6HY72 B6HY78 B6HY80 A0A8V8TM90 ENST00000697150.1 [Q5VWK5-3] A0A1B0GV19 ENST00000697164.1 ENST00000697225.1 B6HY71 B6VNT3 ENST00000637002.1 ENST00000697165.1 ENST00000697155.1 B6HY70 |
