GPIHBP1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GPIHBP1 at tissue level.

III. Associated gene sets

GO_0070328Biological processtriglyceride homeostasis
GO_0017038Biological processprotein import
GO_0006886Biological processintracellular protein transport
GO_0034394Biological processprotein localization to cell surface
GO_0042632Biological processcholesterol homeostasis
GO_0019433Biological processtriglyceride catabolic process
GO_0050821Biological processprotein stabilization
GO_0090321Biological processpositive regulation of chylomicron remnant clearance
GO_0051006Biological processpositive regulation of lipoprotein lipase activity
GO_0045056Biological processtranscytosis
GO_0071503Biological processresponse to heparin
GO_0016324Cellular componentapical plasma membrane
GO_0009897Cellular componentexternal side of plasma membrane
GO_1902494Cellular componentcatalytic complex
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0016323Cellular componentbasolateral plasma membrane
GO_0008289Molecular functionlipid binding
GO_0060230Molecular functionlipoprotein lipase activator activity
GO_0071813Molecular functionlipoprotein particle binding
GO_0035478Molecular functionchylomicron binding
GO_0030550Molecular functionacetylcholine receptor inhibitor activity
GO_0140318Molecular functionprotein transporter activity
GO_0005515Molecular functionprotein binding
GO_0035473Molecular functionlipase binding

IV. Literature review

[source]
Gene nameGPIHBP1
Protein nameGlycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPI-HBP1) (GPI-anchored HDL-binding protein 1) (High density lipoprotein-binding protein 1)
SynonymsHBP1
DescriptionFUNCTION: Mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries (By similarity). Anchors LPL on the surface of endothelial cells in the lumen of blood capillaries (By similarity). Protects LPL against loss of activity, and against ANGPTL4-mediated unfolding . Thereby, plays an important role in lipolytic processing of chylomicrons by LPL, triglyceride metabolism and lipid homeostasis . Binds chylomicrons and phospholipid particles that contain APOA5 . Binds high-density lipoprotein (HDL) and plays a role in the uptake of lipids from HDL (By similarity). .

AccessionsENST00000622500.2
Q8IV16