LAG3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of LAG3 at tissue level.

III. Associated gene sets

GO_0002250Biological processadaptive immune response
GO_0045590Biological processnegative regulation of regulatory T cell differentiation
GO_0032703Biological processnegative regulation of interleukin-2 production
GO_0042110Biological processT cell activation
GO_0050776Biological processregulation of immune response
GO_0045954Biological processpositive regulation of natural killer cell mediated cytotoxicity
GO_0002270Biological processplasmacytoid dendritic cell activation
GO_0007166Biological processcell surface receptor signaling pathway
GO_0042267Biological processnatural killer cell mediated cytotoxicity
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0004888Molecular functiontransmembrane signaling receptor activity
GO_0003823Molecular functionantigen binding
GO_0042289Molecular functionMHC class II protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLAG3
Protein nameLymphocyte activation gene 3 protein (LAG-3) (CD antigen CD223) [Cleaved into: Secreted lymphocyte activation gene 3 protein (sLAG-3)]
SynonymsFDC
DescriptionFUNCTION: Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells . Delivers inhibitory signals upon binding to ligands, such as FGL1 (By similarity). FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function (By similarity). Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity). May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1 (By similarity). Negatively regulates the proliferation, activation, effector function and homeostasis of both CD8(+) and CD4(+) T-cells . Also mediates immune tolerance: constitutively expressed on a subset of regulatory T-cells (Tregs) and contributes to their suppressive function (By similarity). Also acts as a negative regulator of plasmacytoid dendritic cell (pDCs) activation (By similarity). Binds MHC class II (MHC-II); the precise role of MHC-II-binding is however unclear . .; FUNCTION: [Secreted lymphocyte activation gene 3 protein]: May function as a ligand for MHC class II (MHC-II) on antigen-presenting cells (APC), promoting APC activation/maturation and driving Th1 immune response. .

AccessionsENST00000203629.3 [P18627-1]
ENST00000441671.6 [P18627-2]
P18627