MCAM report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MCAM at tissue level.

III. Associated gene sets

GO_0001525Biological processangiogenesis
GO_0061042Biological processvascular wound healing
GO_0030335Biological processpositive regulation of cell migration
GO_0007155Biological processcell adhesion
GO_0003094Biological processglomerular filtration
GO_0009653Biological processanatomical structure morphogenesis
GO_0005615Cellular componentextracellular space
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0005925Cellular componentfocal adhesion

IV. Literature review

[source]
Gene nameMCAM
Protein nameCell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146)
Melanoma adhesion molecule
SynonymsMUC18
DescriptionFUNCTION: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as a surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. .

AccessionsENST00000264036.6 [P43121-1]
P43121
Q9NQ41