Name | Number of supported studies | Average coverage | |
---|---|---|---|
pericyte | 38 studies | 50% ± 24% | |
endothelial cell | 33 studies | 30% ± 12% | |
smooth muscle cell | 29 studies | 46% ± 20% | |
vein endothelial cell | 11 studies | 25% ± 5% | |
endothelial cell of vascular tree | 10 studies | 29% ± 17% | |
capillary endothelial cell | 9 studies | 25% ± 6% | |
endothelial cell of artery | 7 studies | 26% ± 12% | |
adipocyte | 7 studies | 35% ± 13% | |
myofibroblast cell | 5 studies | 37% ± 18% | |
neural crest cell | 3 studies | 21% ± 7% | |
Mueller cell | 3 studies | 26% ± 4% | |
neuron | 3 studies | 24% ± 7% | |
muscle cell | 3 studies | 49% ± 12% | |
oligodendrocyte | 3 studies | 30% ± 11% | |
oligodendrocyte precursor cell | 3 studies | 20% ± 5% | |
connective tissue cell | 3 studies | 36% ± 19% | |
fibroblast | 3 studies | 37% ± 24% |
Insufficient scRNA-seq data for expression of MCAM at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 33536.06 | 457 / 459 | 97% | 54.24 | 1079 / 1118 |
lung | 98% | 21119.35 | 565 / 578 | 89% | 43.41 | 1031 / 1155 |
bladder | 95% | 31863.19 | 20 / 21 | 86% | 37.62 | 433 / 504 |
thymus | 83% | 11003.18 | 545 / 653 | 90% | 45.42 | 544 / 605 |
uterus | 95% | 26346.71 | 162 / 170 | 78% | 51.32 | 357 / 459 |
esophagus | 78% | 26911.57 | 1126 / 1445 | 93% | 51.06 | 170 / 183 |
intestine | 82% | 21519.78 | 790 / 966 | 88% | 37.48 | 465 / 527 |
prostate | 80% | 14724.67 | 197 / 245 | 82% | 33.76 | 413 / 502 |
stomach | 54% | 14304.90 | 195 / 359 | 91% | 50.44 | 261 / 286 |
skin | 35% | 4101.30 | 640 / 1809 | 97% | 295.70 | 459 / 472 |
ovary | 49% | 9913.93 | 88 / 180 | 79% | 26.66 | 341 / 430 |
kidney | 24% | 2784.79 | 21 / 89 | 94% | 144.09 | 849 / 901 |
brain | 32% | 3774.69 | 848 / 2642 | 84% | 43.08 | 591 / 705 |
adrenal gland | 25% | 2447.02 | 65 / 258 | 87% | 77.62 | 201 / 230 |
pancreas | 4% | 371.41 | 14 / 328 | 97% | 52.12 | 172 / 178 |
adipose | 100% | 45816.97 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 153544.73 | 1335 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 96% | 88.53 | 77 / 80 |
heart | 87% | 11646.87 | 747 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 84% | 32.96 | 38 / 45 |
liver | 1% | 83.69 | 2 / 226 | 62% | 25.48 | 252 / 406 |
lymph node | 0% | 0 | 0 / 0 | 59% | 16.79 | 17 / 29 |
spleen | 30% | 2763.98 | 73 / 241 | 0% | 0 | 0 / 0 |
muscle | 20% | 2109.39 | 158 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0001525 | Biological process | angiogenesis |
GO_0061042 | Biological process | vascular wound healing |
GO_0030335 | Biological process | positive regulation of cell migration |
GO_0007155 | Biological process | cell adhesion |
GO_0003094 | Biological process | glomerular filtration |
GO_0009653 | Biological process | anatomical structure morphogenesis |
GO_0005615 | Cellular component | extracellular space |
GO_0009897 | Cellular component | external side of plasma membrane |
GO_0005576 | Cellular component | extracellular region |
GO_0005886 | Cellular component | plasma membrane |
GO_0005925 | Cellular component | focal adhesion |
Gene name | MCAM |
Protein name | Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146) Melanoma adhesion molecule |
Synonyms | MUC18 |
Description | FUNCTION: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as a surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. . |
Accessions | ENST00000264036.6 [P43121-1] P43121 Q9NQ41 |