CCR3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CCR3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CCR3 at tissue level.

III. Associated gene sets

GO_0007188Biological processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO_0006954Biological processinflammatory response
GO_0019722Biological processcalcium-mediated signaling
GO_0045766Biological processpositive regulation of angiogenesis
GO_0006935Biological processchemotaxis
GO_0007155Biological processcell adhesion
GO_0006968Biological processcellular defense response
GO_0006955Biological processimmune response
GO_0070098Biological processchemokine-mediated signaling pathway
GO_0007204Biological processpositive regulation of cytosolic calcium ion concentration
GO_0001938Biological processpositive regulation of endothelial cell proliferation
GO_0060326Biological processcell chemotaxis
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0016493Molecular functionC-C chemokine receptor activity
GO_0004950Molecular functionchemokine receptor activity
GO_0019957Molecular functionC-C chemokine binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCCR3
Protein nameC-C motif chemokine receptor 3 (CC chemokine receptor 3)
CC chemokine receptor 3
C-C chemokine receptor type 3 (C C CKR3) (C-C CKR-3) (CC-CKR-3) (CCR-3) (CCR3) (CKR 3) (CKR3) (Eosinophil eotaxin receptor) (CD antigen CD193)
SynonymsCMKBR3
DescriptionFUNCTION: Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15 . Subsequently transduces a signal by increasing the intracellular calcium ions level . In addition acts as a possible functional receptor for NARS1 . .; FUNCTION: (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection. .

AccessionsENST00000395940.3 [P51677-1]
ENST00000452454.1
Q8TDP7
ENST00000357422.2 [P51677-1]
Q8TDP5
P51677
Q8TDP4
ENST00000545097.1 [P51677-2]
ENST00000395942.2 [P51677-1]
ENST00000457243.1
Q8TDP8
Q96T97
Q96T96