CD86 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	36 studies	33% ± 13%	Explore
conventional dendritic cell	27 studies	36% ± 12%	Explore
non-classical monocyte	25 studies	39% ± 14%	Explore
dendritic cell	23 studies	38% ± 14%	Explore
classical monocyte	21 studies	27% ± 12%	Explore
monocyte	19 studies	30% ± 9%	Explore
myeloid cell	14 studies	34% ± 16%	Explore
microglial cell	12 studies	42% ± 14%	Explore
mononuclear phagocyte	7 studies	31% ± 13%	Explore
memory B cell	5 studies	18% ± 3%	Explore
leukocyte	4 studies	23% ± 9%	Explore
tissue-resident macrophage	3 studies	33% ± 10%	Explore
monocyte-derived dendritic cell	3 studies	38% ± 12%	Explore
alveolar macrophage	3 studies	25% ± 8%	Explore

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CD86 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	879.01	576 / 578	94%	16.56	1088 / 1155
breast	86%	213.19	396 / 459	95%	14.10	1060 / 1118
intestine	93%	280.96	900 / 966	69%	7.17	366 / 527
brain	57%	181.07	1493 / 2642	92%	16.28	649 / 705
bladder	76%	184.48	16 / 21	72%	9.60	361 / 504
adrenal gland	94%	295.18	243 / 258	47%	3.15	109 / 230
esophagus	60%	105.21	870 / 1445	79%	8.17	144 / 183
stomach	57%	101.88	206 / 359	77%	8.71	219 / 286
kidney	44%	109.85	39 / 89	87%	13.61	784 / 901
uterus	50%	79.21	85 / 170	81%	8.58	370 / 459
prostate	77%	152.11	189 / 245	52%	3.17	259 / 502
thymus	54%	105.40	355 / 653	74%	6.69	448 / 605
ovary	43%	71.46	78 / 180	81%	9.01	348 / 430
skin	45%	61.97	813 / 1809	79%	11.89	374 / 472
pancreas	28%	45.49	91 / 328	88%	13.10	157 / 178
lymph node	0%	0	0 / 0	100%	66.41	29 / 29
spleen	100%	1281.44	241 / 241	0%	0	0 / 0
peripheral blood	99%	1780.71	922 / 929	0%	0	0 / 0
adipose	96%	454.44	1158 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	14.59	43 / 45
blood vessel	89%	343.24	1186 / 1335	0%	0	0 / 0
liver	35%	65.11	80 / 226	49%	3.77	197 / 406
heart	44%	81.52	381 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	25%	1.77	20 / 80
muscle	3%	3.54	26 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0023035	Biological process	CD40 signaling pathway
GO_0042102	Biological process	positive regulation of T cell proliferation
GO_1901224	Biological process	positive regulation of non-canonical NF-kappaB signal transduction
GO_0002639	Biological process	positive regulation of immunoglobulin production
GO_0032753	Biological process	positive regulation of interleukin-4 production
GO_0031295	Biological process	T cell costimulation
GO_0032743	Biological process	positive regulation of interleukin-2 production
GO_0006955	Biological process	immune response
GO_0002250	Biological process	adaptive immune response
GO_0046718	Biological process	symbiont entry into host cell
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0042130	Biological process	negative regulation of T cell proliferation
GO_0042113	Biological process	B cell activation
GO_0071222	Biological process	cellular response to lipopolysaccharide
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0032761	Biological process	positive regulation of lymphotoxin A production
GO_0042110	Biological process	T cell activation
GO_1990051	Biological process	activation of protein kinase C activity
GO_0007166	Biological process	cell surface receptor signaling pathway
GO_0045630	Biological process	positive regulation of T-helper 2 cell differentiation
GO_0009897	Cellular component	external side of plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0034451	Cellular component	centriolar satellite
GO_0070062	Cellular component	extracellular exosome
GO_0009986	Cellular component	cell surface
GO_0015026	Molecular function	coreceptor activity
GO_0038023	Molecular function	signaling receptor activity
GO_0048018	Molecular function	receptor ligand activity
GO_0001618	Molecular function	virus receptor activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	CD86
Protein name	T-lymphocyte activation antigen CD86 (Activation B7-2 antigen) (B70) (BU63) (CTLA-4 counter-receptor B7.2) (FUN-1) (CD antigen CD86) CD86 molecule CD86 antigen
Synonyms	CD28LG2 hCG_14759
Description	FUNCTION: Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation . Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity). .; FUNCTION: [Isoform 2]: Interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. .; FUNCTION: (Microbial infection) Acts as a receptor for adenovirus subgroup B. .
Accessions	ENST00000482356.5 ENST00000493101.5 [P42081-5] ENST00000264468.9 [P42081-4] A0A0X9R4E0 C9JXS1 H7C4F8 ENST00000469710.5 [P42081-6] ENST00000330540.7 [P42081-1] ENST00000478741.1 ENST00000393627.6 [P42081-3] P42081

CD86 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review