I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| regulatory T cell | 3 studies | 22% ± 5% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| regulatory T cell | 3 studies | 22% ± 5% |
Insufficient scRNA-seq data for expression of CCR8 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 72% | 6.01 | 418 / 578 | 63% | 1.83 | 731 / 1155 |
| breast | 35% | 1.30 | 162 / 459 | 55% | 2.12 | 613 / 1118 |
| spleen | 86% | 9.34 | 207 / 241 | 0% | 0 | 0 / 0 |
| intestine | 36% | 2.39 | 352 / 966 | 44% | 1.03 | 234 / 527 |
| skin | 49% | 3.02 | 883 / 1809 | 30% | 0.73 | 143 / 472 |
| esophagus | 31% | 1.70 | 450 / 1445 | 42% | 0.98 | 76 / 183 |
| peripheral blood | 71% | 40.95 | 662 / 929 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 71% | 3.31 | 32 / 45 |
| stomach | 23% | 0.70 | 83 / 359 | 48% | 1.25 | 137 / 286 |
| thymus | 40% | 1.89 | 261 / 653 | 30% | 0.99 | 184 / 605 |
| pancreas | 18% | 0.45 | 59 / 328 | 46% | 1.20 | 82 / 178 |
| bladder | 24% | 0.52 | 5 / 21 | 36% | 0.88 | 182 / 504 |
| uterus | 16% | 0.36 | 28 / 170 | 28% | 0.63 | 129 / 459 |
| kidney | 24% | 1.19 | 21 / 89 | 19% | 0.39 | 171 / 901 |
| prostate | 29% | 1.46 | 72 / 245 | 12% | 0.22 | 61 / 502 |
| lymph node | 0% | 0 | 0 / 0 | 41% | 3.90 | 12 / 29 |
| liver | 23% | 0.64 | 52 / 226 | 8% | 0.15 | 31 / 406 |
| adipose | 29% | 1.11 | 355 / 1204 | 0% | 0 | 0 / 0 |
| ovary | 8% | 0.23 | 15 / 180 | 20% | 0.74 | 87 / 430 |
| blood vessel | 16% | 0.59 | 214 / 1335 | 0% | 0 | 0 / 0 |
| adrenal gland | 15% | 0.36 | 38 / 258 | 0% | 0.03 | 1 / 230 |
| brain | 9% | 0.24 | 248 / 2642 | 1% | 0.01 | 5 / 705 |
| muscle | 9% | 0.24 | 69 / 803 | 0% | 0 | 0 / 0 |
| heart | 8% | 0.22 | 69 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 3% | 0.03 | 2 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0006955 | Biological process | immune response |
| GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
| GO_0070098 | Biological process | chemokine-mediated signaling pathway |
| GO_0007204 | Biological process | positive regulation of cytosolic calcium ion concentration |
| GO_0006935 | Biological process | chemotaxis |
| GO_0007155 | Biological process | cell adhesion |
| GO_0019722 | Biological process | calcium-mediated signaling |
| GO_0060326 | Biological process | cell chemotaxis |
| GO_0009897 | Cellular component | external side of plasma membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016493 | Molecular function | C-C chemokine receptor activity |
| GO_0019957 | Molecular function | C-C chemokine binding |
| GO_0015026 | Molecular function | coreceptor activity |
| GO_0004950 | Molecular function | chemokine receptor activity |
| Gene name | CCR8 |
| Protein name | C-C chemokine receptor type 8 (C-C CKR-8) (CC-CKR-8) (CCR-8) (CC chemokine receptor CHEMR1) (CMKBRL2) (Chemokine receptor-like 1) (CKR-L1) (GPR-CY6) (GPRCY6) (TER1) (CD antigen CDw198) C-C motif chemokine receptor 8 C-C chemokine receptor type 8 |
| Synonyms | CMKBR8 CMKBRL2 CKRL1 |
| Description | FUNCTION: Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection. . |
| Accessions | A0A510GAH6 P51685 ENST00000414803.1 C9JIP9 ENST00000326306.5 [P51685-1] |
