FCGRT report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002416Biological processIgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor
GO_0006955Biological processimmune response
GO_0005615Cellular componentextracellular space
GO_0010008Cellular componentendosome membrane
GO_0009897Cellular componentexternal side of plasma membrane
GO_0019864Molecular functionIgG binding
GO_0005515Molecular functionprotein binding
GO_0030881Molecular functionbeta-2-microglobulin binding
GO_0042605Molecular functionpeptide antigen binding

IV. Literature review

[source]
Gene nameFCGRT
Protein nameIgG receptor FcRn large subunit p51 (IgG Fc fragment receptor transporter alpha chain) (Neonatal Fc receptor)
IgG receptor FcRn large subunit p51 (FcRn) (IgG Fc fragment receptor transporter alpha chain) (Neonatal Fc receptor)
Fc gamma receptor and transporter
SynonymsFCRN
DescriptionFUNCTION: Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk . IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation . In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB . .; FUNCTION: (Microbial infection) Acts as an uncoating receptor for a panel of echoviruses including Echovirus 5, 6, 7, 9, 11, 13, 25 and 29. .

AccessionsENST00000426395.7
M0QYN1
ENST00000598076.1
ENST00000598927.5
ENST00000599701.5
M0R0A9
M0R220
ENST00000593381.5
M0QYN9
ENST00000221466.10
ENST00000599988.5
ENST00000598491.5
ENST00000596975.5
M0QYM4
M0R0K7
M0R266
ENST00000598319.5
M0R0H0
ENST00000600273.5
P55899
M0R2T3