KIT | OmnibusX

Name	Number of supported studies	Average coverage
mast cell	34 studies	69% ± 18%	Explore
ionocyte	5 studies	43% ± 16%	Explore
interneuron	5 studies	43% ± 19%	Explore
renal alpha-intercalated cell	5 studies	41% ± 9%	Explore
brush cell	5 studies	47% ± 20%	Explore
endothelial cell	4 studies	27% ± 3%	Explore
innate lymphoid cell	4 studies	29% ± 5%	Explore
GABAergic neuron	4 studies	26% ± 8%	Explore
interstitial cell of Cajal	3 studies	55% ± 20%	Explore
group 3 innate lymphoid cell	3 studies	52% ± 4%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	24% ± 3%	Explore

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of KIT at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	98%	2864.22	569 / 578	74%	28.50	853 / 1155
breast	89%	6819.27	409 / 459	78%	24.62	874 / 1118
brain	81%	1887.67	2128 / 2642	82%	13.97	576 / 705
kidney	97%	1938.84	86 / 89	66%	32.15	591 / 901
thymus	100%	3461.99	650 / 653	60%	23.95	362 / 605
stomach	100%	2833.83	359 / 359	45%	6.17	128 / 286
intestine	99%	2859.80	954 / 966	42%	4.96	219 / 527
skin	73%	2381.30	1313 / 1809	67%	61.46	316 / 472
bladder	100%	2514.05	21 / 21	39%	13.07	198 / 504
esophagus	93%	3840.26	1340 / 1445	46%	5.56	84 / 183
prostate	86%	1154.69	211 / 245	46%	3.98	232 / 502
uterus	86%	1196.69	146 / 170	34%	5.09	158 / 459
ovary	96%	3977.17	173 / 180	10%	0.92	45 / 430
ureter	0%	0	0 / 0	100%	4.98	1 / 1
eye	0%	0	0 / 0	98%	176.50	78 / 80
adipose	89%	1487.18	1066 / 1204	0%	0	0 / 0
pancreas	13%	81.59	41 / 328	68%	9.28	121 / 178
blood vessel	70%	767.26	937 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	62%	10.80	28 / 45
adrenal gland	2%	12.07	4 / 258	48%	8.63	111 / 230
spleen	22%	153.41	52 / 241	0%	0	0 / 0
heart	9%	66.19	74 / 861	0%	0	0 / 0
liver	2%	9.27	4 / 226	5%	0.52	21 / 406
lymph node	0%	0	0 / 0	3%	0.15	1 / 29
muscle	3%	18.82	22 / 803	0%	0	0 / 0
peripheral blood	0%	0.89	1 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0097324	Biological process	melanocyte migration
GO_0006954	Biological process	inflammatory response
GO_0051093	Biological process	negative regulation of developmental process
GO_0001541	Biological process	ovarian follicle development
GO_1904349	Biological process	positive regulation of small intestine smooth muscle contraction
GO_0007275	Biological process	multicellular organism development
GO_0038162	Biological process	erythropoietin-mediated signaling pathway
GO_0046686	Biological process	response to cadmium ion
GO_0043303	Biological process	mast cell degranulation
GO_0030036	Biological process	actin cytoskeleton organization
GO_0051897	Biological process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0050910	Biological process	detection of mechanical stimulus involved in sensory perception of sound
GO_0002327	Biological process	immature B cell differentiation
GO_0097326	Biological process	melanocyte adhesion
GO_0060326	Biological process	cell chemotaxis
GO_0035234	Biological process	ectopic germ cell programmed cell death
GO_0030183	Biological process	B cell differentiation
GO_0070668	Biological process	positive regulation of mast cell proliferation
GO_0060374	Biological process	mast cell differentiation
GO_0050673	Biological process	epithelial cell proliferation
GO_0002244	Biological process	hematopoietic progenitor cell differentiation
GO_0007165	Biological process	signal transduction
GO_0043069	Biological process	negative regulation of programmed cell death
GO_0008542	Biological process	visual learning
GO_0120072	Biological process	positive regulation of pyloric antrum smooth muscle contraction
GO_0043473	Biological process	pigmentation
GO_0035701	Biological process	hematopoietic stem cell migration
GO_0048565	Biological process	digestive tract development
GO_0002318	Biological process	myeloid progenitor cell differentiation
GO_0046777	Biological process	protein autophosphorylation
GO_0002551	Biological process	mast cell chemotaxis
GO_0035162	Biological process	embryonic hemopoiesis
GO_0042531	Biological process	positive regulation of tyrosine phosphorylation of STAT protein
GO_0006687	Biological process	glycosphingolipid metabolic process
GO_0030097	Biological process	hemopoiesis
GO_1904251	Biological process	regulation of bile acid metabolic process
GO_0051091	Biological process	positive regulation of DNA-binding transcription factor activity
GO_0043586	Biological process	tongue development
GO_0043406	Biological process	positive regulation of MAP kinase activity
GO_0030217	Biological process	T cell differentiation
GO_0019827	Biological process	stem cell population maintenance
GO_0032765	Biological process	positive regulation of mast cell cytokine production
GO_0038093	Biological process	Fc receptor signaling pathway
GO_0008584	Biological process	male gonad development
GO_0002320	Biological process	lymphoid progenitor cell differentiation
GO_0046427	Biological process	positive regulation of receptor signaling pathway via JAK-STAT
GO_0042127	Biological process	regulation of cell population proliferation
GO_0035019	Biological process	somatic stem cell population maintenance
GO_0019221	Biological process	cytokine-mediated signaling pathway
GO_0038109	Biological process	Kit signaling pathway
GO_0007283	Biological process	spermatogenesis
GO_0048170	Biological process	positive regulation of long-term neuronal synaptic plasticity
GO_1904343	Biological process	positive regulation of colon smooth muscle contraction
GO_0030032	Biological process	lamellipodium assembly
GO_0043410	Biological process	positive regulation of MAPK cascade
GO_0035855	Biological process	megakaryocyte development
GO_0030218	Biological process	erythrocyte differentiation
GO_0002732	Biological process	positive regulation of dendritic cell cytokine production
GO_0035556	Biological process	intracellular signal transduction
GO_0030318	Biological process	melanocyte differentiation
GO_0030335	Biological process	positive regulation of cell migration
GO_2000242	Biological process	negative regulation of reproductive process
GO_0008360	Biological process	regulation of cell shape
GO_0031274	Biological process	positive regulation of pseudopodium assembly
GO_0045747	Biological process	positive regulation of Notch signaling pathway
GO_0048863	Biological process	stem cell differentiation
GO_0008354	Biological process	germ cell migration
GO_1905065	Biological process	positive regulation of vascular associated smooth muscle cell differentiation
GO_0007286	Biological process	spermatid development
GO_0070662	Biological process	mast cell proliferation
GO_0001669	Cellular component	acrosomal vesicle
GO_0001650	Cellular component	fibrillar center
GO_0005615	Cellular component	extracellular space
GO_0009897	Cellular component	external side of plasma membrane
GO_0043235	Cellular component	receptor complex
GO_0005886	Cellular component	plasma membrane
GO_0009898	Cellular component	cytoplasmic side of plasma membrane
GO_0005911	Cellular component	cell-cell junction
GO_0019955	Molecular function	cytokine binding
GO_0042169	Molecular function	SH2 domain binding
GO_0005524	Molecular function	ATP binding
GO_0046872	Molecular function	metal ion binding
GO_0004713	Molecular function	protein tyrosine kinase activity
GO_0002020	Molecular function	protease binding
GO_0005515	Molecular function	protein binding
GO_0042803	Molecular function	protein homodimerization activity
GO_0005020	Molecular function	stem cell factor receptor activity
GO_0004714	Molecular function	transmembrane receptor protein tyrosine kinase activity
GO_0019838	Molecular function	growth factor binding

IV. Literature review

[source]

Gene name	KIT
Protein name	Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117) Mast/stem cell growth factor receptor Kit (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) KIT protein Platelet-derived growth factor receptor-like protein KIT proto-oncogene, receptor tyrosine kinase receptor protein-tyrosine kinase (EC 2.7.10.1) V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein C-Kit protooncogene Mast/stem cell growth factor receptor variant (EC 2.7.10.1) Mast/stem cell growth factor receptor (EC 2.7.10.1) Alternative protein KIT
Synonyms	SCFR
Description	FUNCTION: Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1. .
Accessions	L8E780 A0A8I5KS03 P10721 ENST00000412167.7 ENST00000692783.1 A0A8I5QKL5 B6E0M6 B6DXN3 A0A8I5KPX7 A0A8J8Z860 A0A8I5KXA4 ENST00000689994.1 Q9UMA0 ENST00000687295.1 [P10721-2] D5MAV9 ENST00000690519.1 A0A0U2N547 ENST00000686011.1 A0A8I5KRE7 Q8TCG9 E2I6G0 Q15999 ENST00000288135.6 [P10721-1] ENST00000690543.1 ENST00000687109.1 ENST00000689832.1 A0A8I5KR87 A0A8I5QKP7 D5MAV8 ENST00000687246.1 A0A8I5KQZ6 ENST00000685816.1

KIT report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review