ENPP3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ENPP3 at tissue level.

III. Associated gene sets

GO_0055062Biological processphosphate ion homeostasis
GO_0006220Biological processpyrimidine nucleotide metabolic process
GO_0033007Biological processnegative regulation of mast cell activation involved in immune response
GO_0070667Biological processnegative regulation of mast cell proliferation
GO_0006796Biological processphosphate-containing compound metabolic process
GO_0046034Biological processATP metabolic process
GO_0050728Biological processnegative regulation of inflammatory response
GO_0030505Biological processinorganic diphosphate transport
GO_0009143Biological processnucleoside triphosphate catabolic process
GO_0002276Biological processbasophil activation involved in immune response
GO_0016324Cellular componentapical plasma membrane
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0070062Cellular componentextracellular exosome
GO_0047710Molecular functionbis(5'-adenosyl)-triphosphatase activity
GO_0003676Molecular functionnucleic acid binding
GO_0034432Molecular functionbis(5'-adenosyl)-pentaphosphatase activity
GO_0004528Molecular functionphosphodiesterase I activity
GO_0004081Molecular functionbis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
GO_0047429Molecular functionnucleoside triphosphate diphosphatase activity
GO_0008270Molecular functionzinc ion binding
GO_0005509Molecular functioncalcium ion binding

IV. Literature review

[source]
Gene nameENPP3
Protein nameEctonucleotide pyrophosphatase/phosphodiesterase 3
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (EC 3.1.4.1) (EC 3.6.1.9) (Phosphodiesterase I beta) (Phosphodiesterase I/nucleotide pyrophosphatase 3)
DJ334I18.1 (Ectonucleotide pyrophosphatase/phosphodiesterase 3)
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (E-NPP 3) (NPP3) (Phosphodiesterase I beta) (PD-Ibeta) (Phosphodiesterase I/nucleotide pyrophosphatase 3) (CD antigen CD203c) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (NPPase) (EC 3.6.1.9) (Nucleotide diphosphatase)]
SynonymsPDNP3
DescriptionFUNCTION: Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP . Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells (By similarity). Has also alkaline phosphodiesterase activity . .

AccessionsENST00000357639.8
ENST00000423831.5
O14638
F8W6H5
E7ETI7
E9PDB4
ENST00000414305.5
ENST00000427707.5
ENST00000358229.6
Q9H515