GFRAL | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of GFRAL at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adipose	70%	13.37	842 / 1204	0%	0	0 / 0
breast	64%	8.22	292 / 459	0%	0.00	1 / 1118
brain	35%	1.24	918 / 2642	0%	0	0 / 705
bladder	24%	0.57	5 / 21	0%	0	0 / 504
prostate	20%	0.67	48 / 245	0%	0	0 / 502
lung	18%	0.59	104 / 578	0%	0.01	4 / 1155
skin	18%	0.64	330 / 1809	0%	0	0 / 472
intestine	15%	0.44	148 / 966	0%	0.00	1 / 527
esophagus	10%	0.30	151 / 1445	1%	0.01	1 / 183
blood vessel	10%	0.41	130 / 1335	0%	0	0 / 0
heart	9%	0.25	80 / 861	0%	0	0 / 0
kidney	9%	0.20	8 / 89	0%	0.00	1 / 901
muscle	8%	0.23	65 / 803	0%	0	0 / 0
uterus	6%	0.19	11 / 170	1%	0.03	3 / 459
pancreas	6%	0.14	19 / 328	0%	0	0 / 178
thymus	5%	0.12	32 / 653	0%	0	0 / 605
spleen	4%	0.11	10 / 241	0%	0	0 / 0
stomach	3%	0.10	12 / 359	1%	0.01	2 / 286
ovary	3%	0.09	6 / 180	0%	0	0 / 430
adrenal gland	3%	0.07	7 / 258	0%	0	0 / 230
liver	3%	0.07	6 / 226	0%	0	0 / 406
peripheral blood	2%	0.04	18 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0032099	Biological process	negative regulation of appetite
GO_0160144	Biological process	GDF15-GFRAL signaling pathway
GO_0043410	Biological process	positive regulation of MAPK cascade
GO_0002023	Biological process	reduction of food intake in response to dietary excess
GO_0051897	Biological process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0031098	Biological process	stress-activated protein kinase signaling cascade
GO_2001240	Biological process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO_1901558	Biological process	response to metformin
GO_0043524	Biological process	negative regulation of neuron apoptotic process
GO_0007399	Biological process	nervous system development
GO_0009897	Cellular component	external side of plasma membrane
GO_0043235	Cellular component	receptor complex
GO_0005886	Cellular component	plasma membrane
GO_0005654	Cellular component	nucleoplasm
GO_0005925	Cellular component	focal adhesion
GO_0015629	Cellular component	actin cytoskeleton
GO_0038023	Molecular function	signaling receptor activity
GO_0005179	Molecular function	hormone activity
GO_0016167	Molecular function	glial cell-derived neurotrophic factor receptor activity
GO_0005515	Molecular function	protein binding
GO_0030971	Molecular function	receptor tyrosine kinase binding

Gene name	GFRAL
Protein name	GDNF family receptor alpha-like
Synonyms	UNQ9356/PRO34128 C6orf144
Description	FUNCTION: Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses . Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways. .
Accessions	Q6UXV0 ENST00000340465.2

GFRAL report