Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| fibroblast | 27 studies | 48% ± 22% | |
| connective tissue cell | 12 studies | 40% ± 18% | |
| myofibroblast cell | 6 studies | 29% ± 10% | |
| retinal pigment epithelial cell | 4 studies | 43% ± 18% | |
| adventitial cell | 4 studies | 42% ± 7% | |
| melanocyte | 3 studies | 24% ± 7% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| uterus | 3 studies | 18% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 99% | 15745.75 | 455 / 459 | 95% | 95.26 | 1065 / 1118 |
| skin | 100% | 17988.15 | 1808 / 1809 | 90% | 127.00 | 425 / 472 |
| intestine | 96% | 4819.57 | 927 / 966 | 79% | 30.76 | 417 / 527 |
| lung | 80% | 2710.79 | 464 / 578 | 85% | 33.01 | 979 / 1155 |
| bladder | 95% | 5443.86 | 20 / 21 | 69% | 29.22 | 348 / 504 |
| uterus | 100% | 15445.36 | 170 / 170 | 59% | 38.68 | 272 / 459 |
| esophagus | 87% | 3682.17 | 1256 / 1445 | 72% | 24.75 | 131 / 183 |
| ovary | 99% | 5384.42 | 179 / 180 | 44% | 18.59 | 189 / 430 |
| stomach | 57% | 2464.81 | 206 / 359 | 79% | 30.00 | 225 / 286 |
| prostate | 83% | 2609.18 | 203 / 245 | 43% | 7.45 | 218 / 502 |
| thymus | 90% | 2833.09 | 588 / 653 | 36% | 8.80 | 219 / 605 |
| adipose | 99% | 13096.93 | 1190 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 99% | 98.59 | 79 / 80 |
| blood vessel | 96% | 4934.67 | 1283 / 1335 | 0% | 0 | 0 / 0 |
| pancreas | 4% | 74.80 | 12 / 328 | 91% | 65.72 | 162 / 178 |
| lymph node | 0% | 0 | 0 / 0 | 83% | 51.08 | 24 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 69% | 25.50 | 31 / 45 |
| spleen | 62% | 1216.61 | 149 / 241 | 0% | 0 | 0 / 0 |
| kidney | 21% | 536.56 | 19 / 89 | 23% | 21.00 | 209 / 901 |
| heart | 36% | 944.67 | 306 / 861 | 0% | 0 | 0 / 0 |
| brain | 2% | 39.55 | 59 / 2642 | 21% | 4.82 | 150 / 705 |
| adrenal gland | 18% | 323.26 | 46 / 258 | 5% | 1.51 | 12 / 230 |
| muscle | 13% | 343.07 | 105 / 803 | 0% | 0 | 0 / 0 |
| liver | 1% | 12.60 | 2 / 226 | 11% | 6.90 | 44 / 406 |
| peripheral blood | 1% | 22.56 | 13 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0071560 | Biological process | cellular response to transforming growth factor beta stimulus |
| GO_0006590 | Biological process | thyroid hormone generation |
| GO_0001957 | Biological process | intramembranous ossification |
| GO_0032868 | Biological process | response to insulin |
| GO_0014070 | Biological process | response to organic cyclic compound |
| GO_0022617 | Biological process | extracellular matrix disassembly |
| GO_0045471 | Biological process | response to ethanol |
| GO_0030574 | Biological process | collagen catabolic process |
| GO_1903131 | Biological process | mononuclear cell differentiation |
| GO_0006955 | Biological process | immune response |
| GO_0071356 | Biological process | cellular response to tumor necrosis factor |
| GO_0006508 | Biological process | proteolysis |
| GO_0010952 | Biological process | positive regulation of peptidase activity |
| GO_0045453 | Biological process | bone resorption |
| GO_0006915 | Biological process | apoptotic process |
| GO_0000423 | Biological process | mitophagy |
| GO_0051603 | Biological process | proteolysis involved in protein catabolic process |
| GO_2001235 | Biological process | positive regulation of apoptotic signaling pathway |
| GO_0061037 | Biological process | negative regulation of cartilage development |
| GO_0034224 | Biological process | cellular response to zinc ion starvation |
| GO_0016324 | Cellular component | apical plasma membrane |
| GO_0005615 | Cellular component | extracellular space |
| GO_0009897 | Cellular component | external side of plasma membrane |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005764 | Cellular component | lysosome |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0043202 | Cellular component | lysosomal lumen |
| GO_0036021 | Cellular component | endolysosome lumen |
| GO_0008656 | Molecular function | cysteine-type endopeptidase activator activity involved in apoptotic process |
| GO_0001968 | Molecular function | fibronectin binding |
| GO_0043394 | Molecular function | proteoglycan binding |
| GO_0008234 | Molecular function | cysteine-type peptidase activity |
| GO_0004197 | Molecular function | cysteine-type endopeptidase activity |
| GO_0005518 | Molecular function | collagen binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0004252 | Molecular function | serine-type endopeptidase activity |
| Gene name | CTSK |
| Protein name | Mutated cathepsin K Cathepsin K Cathepsin K (EC 3.4.22.38) (Cathepsin O) (Cathepsin O2) (Cathepsin X) Cathepsin K (EC 3.4.22.38) |
| Synonyms | CTSO CTSO2 hCG_39377 |
| Description | FUNCTION: Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen . . |
| Accessions | Q2XNE6 A0A7I2V354 A0A7I2V4B6 A0A7I2V4B1 ENST00000676824.1 ENST00000271651.8 P43235 Q6FHN2 ENST00000676716.1 ENST00000677887.1 A0A7I2V617 A0A7I2V5Y9 A0A7I2V5Y6 A0A7I2YQX0 Q5QP40 ENST00000678275.1 H7CEH5 ENST00000678337.1 ENST00000676751.1 ENST00000676966.1 ENST00000676970.1 ENST00000676680.1 ENST00000443913.2 A0A7I2V2M6 ENST00000679260.1 |
