CLCN3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0048388Biological processendosomal lumen acidification
GO_0008344Biological processadult locomotory behavior
GO_0045494Biological processphotoreceptor cell maintenance
GO_1903428Biological processpositive regulation of reactive oxygen species biosynthetic process
GO_0006885Biological processregulation of pH
GO_0006911Biological processphagocytosis, engulfment
GO_0097401Biological processsynaptic vesicle lumen acidification
GO_1902476Biological processchloride transmembrane transport
GO_0051932Biological processsynaptic transmission, GABAergic
GO_0045794Biological processnegative regulation of cell volume
GO_0035249Biological processsynaptic transmission, glutamatergic
GO_0032587Cellular componentruffle membrane
GO_0098978Cellular componentglutamatergic synapse
GO_0009897Cellular componentexternal side of plasma membrane
GO_0031902Cellular componentlate endosome membrane
GO_0005886Cellular componentplasma membrane
GO_0031410Cellular componentcytoplasmic vesicle
GO_0012506Cellular componentvesicle membrane
GO_0016020Cellular componentmembrane
GO_0055037Cellular componentrecycling endosome
GO_0005769Cellular componentearly endosome
GO_0031901Cellular componentearly endosome membrane
GO_0030672Cellular componentsynaptic vesicle membrane
GO_0043679Cellular componentaxon terminus
GO_0005794Cellular componentGolgi apparatus
GO_0042581Cellular componentspecific granule
GO_0098982Cellular componentGABA-ergic synapse
GO_0009986Cellular componentcell surface
GO_0000139Cellular componentGolgi membrane
GO_0008021Cellular componentsynaptic vesicle
GO_0045335Cellular componentphagocytic vesicle
GO_0005770Cellular componentlate endosome
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0010008Cellular componentendosome membrane
GO_0030141Cellular componentsecretory granule
GO_0005765Cellular componentlysosomal membrane
GO_0072320Molecular functionvolume-sensitive chloride channel activity
GO_0015297Molecular functionantiporter activity
GO_0030165Molecular functionPDZ domain binding
GO_0005247Molecular functionvoltage-gated chloride channel activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0005254Molecular functionchloride channel activity

IV. Literature review

[source]
Gene nameCLCN3
Protein nameH(+)/Cl(-) exchange transporter 3 (Chloride channel protein 3) (ClC-3) (Chloride transporter ClC-3)
Chloride channel protein
Chloride voltage-gated channel 3
CLCN3 protein
Synonyms
DescriptionFUNCTION: [Isoform 1]: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons (By similarity). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons . The presence of conserved gating glutamate residues is typical for family members that function as antiporters . .; FUNCTION: [Isoform 2]: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons. .

AccessionsE9PE15
ENST00000511092.5
D6RDZ6
ENST00000513761.6 [P51790-1]
ENST00000507875.6
P51790
H0Y8Z8
Q7Z4M4
ENST00000515420.1
ENST00000347613.9 [P51790-2]
ENST00000360642.7 [P51790-4]
ENST00000512813.5
D6RIX3