PRNP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051260Biological processprotein homooligomerization
GO_0070885Biological processnegative regulation of calcineurin-NFAT signaling cascade
GO_1904645Biological processresponse to amyloid-beta
GO_0046686Biological processresponse to cadmium ion
GO_0050730Biological processregulation of peptidyl-tyrosine phosphorylation
GO_0001933Biological processnegative regulation of protein phosphorylation
GO_0043066Biological processnegative regulation of apoptotic process
GO_0032689Biological processnegative regulation of type II interferon production
GO_1900272Biological processnegative regulation of long-term synaptic potentiation
GO_0006979Biological processresponse to oxidative stress
GO_0051726Biological processregulation of cell cycle
GO_0071466Biological processcellular response to xenobiotic stimulus
GO_0010955Biological processnegative regulation of protein processing
GO_1901379Biological processregulation of potassium ion transmembrane transport
GO_0090314Biological processpositive regulation of protein targeting to membrane
GO_0097062Biological processdendritic spine maintenance
GO_1902951Biological processnegative regulation of dendritic spine maintenance
GO_0032700Biological processnegative regulation of interleukin-17 production
GO_0006878Biological processintracellular copper ion homeostasis
GO_1900449Biological processregulation of glutamate receptor signaling pathway
GO_0032703Biological processnegative regulation of interleukin-2 production
GO_1902430Biological processnegative regulation of amyloid-beta formation
GO_0031648Biological processprotein destabilization
GO_0043433Biological processnegative regulation of DNA-binding transcription factor activity
GO_1902992Biological processnegative regulation of amyloid precursor protein catabolic process
GO_1904646Biological processcellular response to amyloid-beta
GO_0050850Biological processpositive regulation of calcium-mediated signaling
GO_0007611Biological processlearning or memory
GO_1905664Biological processregulation of calcium ion import across plasma membrane
GO_0050860Biological processnegative regulation of T cell receptor signaling pathway
GO_0007616Biological processlong-term memory
GO_1990535Biological processneuron projection maintenance
GO_0043525Biological processpositive regulation of neuron apoptotic process
GO_1903078Biological processpositive regulation of protein localization to plasma membrane
GO_0071280Biological processcellular response to copper ion
GO_0050731Biological processpositive regulation of peptidyl-tyrosine phosphorylation
GO_0046007Biological processnegative regulation of activated T cell proliferation
GO_1900451Biological processpositive regulation of glutamate receptor signaling pathway
GO_0045121Cellular componentmembrane raft
GO_0043195Cellular componentterminal bouton
GO_0098794Cellular componentpostsynapse
GO_0009986Cellular componentcell surface
GO_0070062Cellular componentextracellular exosome
GO_0019898Cellular componentextrinsic component of membrane
GO_0030425Cellular componentdendrite
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0005794Cellular componentGolgi apparatus
GO_0016234Cellular componentinclusion body
GO_0005783Cellular componentendoplasmic reticulum
GO_0014069Cellular componentpostsynaptic density
GO_0005737Cellular componentcytoplasm
GO_0005741Cellular componentmitochondrial outer membrane
GO_0005829Cellular componentcytosol
GO_0031965Cellular componentnuclear membrane
GO_0140677Molecular functionmolecular function activator activity
GO_0042802Molecular functionidentical protein binding
GO_0043008Molecular functionATP-dependent protein binding
GO_0140693Molecular functionmolecular condensate scaffold activity
GO_0038023Molecular functionsignaling receptor activity
GO_1903135Molecular functioncupric ion binding
GO_0060090Molecular functionmolecular adaptor activity
GO_0001540Molecular functionamyloid-beta binding
GO_0031805Molecular functiontype 8 metabotropic glutamate receptor binding
GO_0002020Molecular functionprotease binding
GO_0051087Molecular functionprotein-folding chaperone binding
GO_0005539Molecular functionglycosaminoglycan binding
GO_0044325Molecular functiontransmembrane transporter binding
GO_0005507Molecular functioncopper ion binding
GO_0005515Molecular functionprotein binding
GO_0031802Molecular functiontype 5 metabotropic glutamate receptor binding
GO_0015631Molecular functiontubulin binding
GO_0044877Molecular functionprotein-containing complex binding
GO_0019828Molecular functionaspartic-type endopeptidase inhibitor activity
GO_0005521Molecular functionlamin binding
GO_0008017Molecular functionmicrotubule binding
GO_1903136Molecular functioncuprous ion binding

IV. Literature review

[source]
Gene namePRNP
Protein nameAlternative prion protein
Prion protein
PrP amyloid
Alternative prion protein (AltPrP)
Major prion protein
Major prion protein (PrP) (ASCR) (PrP27-30) (PrP33-35C) (CD antigen CD230)
SynonymshCG_1785425
ALTPRP
PRP
PRIP
DescriptionFUNCTION: Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity). .

AccessionsK0P2W7
Q53YK7
X6RKS3
A0A6J4EE43
B2NI05
Q7KYY8
Q540C4
D4P3Q7
ENST00000457586
Q86XR1
P04156
Q6FGN5
ENST00000457586.2 [P04156-1]
B2NI04
Q6FGR8
O75942
A1YVW6
Q16409
Q6SES1
A2A2V1
F7VJQ1
ENST00000379440.9 [P04156-1]
ENST00000424424.2 [P04156-1]
ENST00000430350.2 [P04156-1]
ENST00000424424