LILRB1 | OmnibusX

Name	Number of supported studies	Average coverage
non-classical monocyte	25 studies	53% ± 17%	Explore
classical monocyte	17 studies	29% ± 8%	Explore
monocyte	15 studies	29% ± 10%	Explore
plasmacytoid dendritic cell	12 studies	23% ± 6%	Explore
macrophage	11 studies	27% ± 6%	Explore
myeloid cell	7 studies	28% ± 11%	Explore
conventional dendritic cell	5 studies	29% ± 13%	Explore
B cell	5 studies	22% ± 6%	Explore
microglial cell	5 studies	25% ± 7%	Explore
intermediate monocyte	3 studies	36% ± 14%	Explore
mononuclear phagocyte	3 studies	27% ± 11%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	4 studies	20% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	1783.50	578 / 578	86%	6.72	994 / 1155
breast	62%	187.87	285 / 459	82%	5.34	917 / 1118
kidney	57%	240.81	51 / 89	83%	7.79	747 / 901
brain	51%	205.77	1343 / 2642	83%	7.57	586 / 705
intestine	79%	549.18	762 / 966	54%	3.21	286 / 527
bladder	71%	294.10	15 / 21	52%	3.30	260 / 504
adrenal gland	91%	367.64	236 / 258	30%	1.20	70 / 230
stomach	45%	152.95	163 / 359	68%	4.37	194 / 286
esophagus	38%	113.85	547 / 1445	66%	3.27	120 / 183
liver	71%	332.07	161 / 226	32%	1.58	129 / 406
prostate	72%	291.34	176 / 245	30%	1.03	149 / 502
lymph node	0%	0	0 / 0	100%	43.65	29 / 29
peripheral blood	100%	4495.87	929 / 929	0%	0	0 / 0
spleen	100%	7980.77	241 / 241	0%	0	0 / 0
thymus	50%	192.41	328 / 653	46%	2.21	277 / 605
uterus	36%	85.66	61 / 170	56%	3.10	256 / 459
adipose	90%	427.82	1088 / 1204	0%	0	0 / 0
ovary	20%	42.76	36 / 180	69%	4.11	297 / 430
pancreas	20%	61.66	66 / 328	67%	3.91	119 / 178
tonsil	0%	0	0 / 0	76%	5.38	34 / 45
skin	2%	3.15	33 / 1809	63%	6.70	299 / 472
blood vessel	48%	219.15	645 / 1335	0%	0	0 / 0
heart	32%	96.75	274 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	13%	0.46	10 / 80
muscle	1%	2.68	12 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0031623	Biological process	receptor internalization
GO_0045786	Biological process	negative regulation of cell cycle
GO_0051926	Biological process	negative regulation of calcium ion transport
GO_2001205	Biological process	negative regulation of osteoclast development
GO_0007165	Biological process	signal transduction
GO_0009615	Biological process	response to virus
GO_0051607	Biological process	defense response to virus
GO_0010628	Biological process	positive regulation of gene expression
GO_0045806	Biological process	negative regulation of endocytosis
GO_0001915	Biological process	negative regulation of T cell mediated cytotoxicity
GO_0032695	Biological process	negative regulation of interleukin-12 production
GO_0097028	Biological process	dendritic cell differentiation
GO_0002767	Biological process	immune response-inhibiting cell surface receptor signaling pathway
GO_2001199	Biological process	negative regulation of dendritic cell differentiation
GO_0032693	Biological process	negative regulation of interleukin-10 production
GO_0140105	Biological process	interleukin-10-mediated signaling pathway
GO_0002250	Biological process	adaptive immune response
GO_0071635	Biological process	negative regulation of transforming growth factor beta production
GO_0045953	Biological process	negative regulation of natural killer cell mediated cytotoxicity
GO_0042130	Biological process	negative regulation of T cell proliferation
GO_0046636	Biological process	negative regulation of alpha-beta T cell activation
GO_0002764	Biological process	immune response-regulating signaling pathway
GO_2001189	Biological process	negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
GO_0032688	Biological process	negative regulation of interferon-beta production
GO_0071222	Biological process	cellular response to lipopolysaccharide
GO_0060907	Biological process	positive regulation of macrophage cytokine production
GO_0032689	Biological process	negative regulation of type II interferon production
GO_0014063	Biological process	negative regulation of serotonin secretion
GO_0032729	Biological process	positive regulation of type II interferon production
GO_0002309	Biological process	T cell proliferation involved in immune response
GO_0032720	Biological process	negative regulation of tumor necrosis factor production
GO_2000669	Biological process	negative regulation of dendritic cell apoptotic process
GO_0043065	Biological process	positive regulation of apoptotic process
GO_2001193	Biological process	positive regulation of gamma-delta T cell activation involved in immune response
GO_0002230	Biological process	positive regulation of defense response to virus by host
GO_0002719	Biological process	negative regulation of cytokine production involved in immune response
GO_2001186	Biological process	negative regulation of CD8-positive, alpha-beta T cell activation
GO_0032945	Biological process	negative regulation of mononuclear cell proliferation
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0002774	Biological process	Fc receptor mediated inhibitory signaling pathway
GO_0009897	Cellular component	external side of plasma membrane
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0005737	Cellular component	cytoplasm
GO_0042803	Molecular function	protein homodimerization activity
GO_0032393	Molecular function	MHC class I receptor activity
GO_0032396	Molecular function	inhibitory MHC class I receptor activity
GO_0001540	Molecular function	amyloid-beta binding
GO_0023029	Molecular function	MHC class Ib protein binding
GO_0030107	Molecular function	HLA-A specific inhibitory MHC class I receptor activity
GO_0042288	Molecular function	MHC class I protein binding
GO_0042169	Molecular function	SH2 domain binding
GO_0008157	Molecular function	protein phosphatase 1 binding
GO_0023025	Molecular function	MHC class Ib protein complex binding
GO_0032394	Molecular function	MHC class Ib receptor activity
GO_0030109	Molecular function	HLA-B specific inhibitory MHC class I receptor activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	LILRB1
Protein name	LIR-1 (Leukocyte immunoglobulin like receptor B1) LIR-1 (Leukocyte immunoglobulin-like receptor subfamily B member 1) Leukocyte immunoglobulin-like receptor subfamily B member 1 Leukocyte immunoglobulin like receptor B1 Leukocyte immunoglobulin-like receptor subfamily B member 1 (LIR-1) (Leukocyte immunoglobulin-like receptor 1) (CD85 antigen-like family member J) (Immunoglobulin-like transcript 2) (ILT-2) (Monocyte/macrophage immunoglobulin-like receptor 7) (MIR-7) (CD antigen CD85j) LIR-1
Synonyms	ILT2 MIR7 LIR1
Description	FUNCTION: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles . Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of FCER1A signaling and serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions . Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide . Upon interaction with peptide-bound HLA-G-B2M complex, triggers secretion of growth-promoting factors by decidual NK cells . Reprograms B cells toward an immune suppressive phenotype . .
Accessions	A0A087WSX8 ENST00000617686.4 [Q8NHL6-4] D9IDM8 A0A0G2JP64 ENST00000612636.4 [Q8NHL6-3] A0A0G2JQ15 ENST00000324602.12 A0A0G2JLS4 A0A0B4J1W1 A0A0G2JNM2 ENST00000610641.4 ENST00000421584.5 A8MVE2 ENST00000396331.5 ENST00000615841.4 ENST00000616890.4 D9IDM5 A0A0G2JQ44 ENST00000610815.4 ENST00000396317.5 ENST00000611295.4 ENST00000427581.6 D9IDM4 ENST00000619395.4 Q8NHL6 A0A0G2JQ46 ENST00000615004.3 A0A0G2JNK9 ENST00000619093.4 D9IDM9 ENST00000616565.4 ENST00000613145.4 F6TER3 ENST00000618681.4 [Q8NHL6-2] ENST00000396332.8 A0A0G2JMG0 ENST00000620471.4 F6RVM3 ENST00000616408.4 ENST00000396315.5 ENST00000612335.3 D9IDM6 A0A0G2JNR3 ENST00000396327.7 ENST00000620642.4 ENST00000618055.4 [Q8NHL6-1] D9IDM7 ENST00000613400.4 D9IDN1 ENST00000619118.1 A0A0G2JNQ6 A0A087WSV6 A0A0G2JP80 ENST00000610752.4 ENST00000610532.4

LILRB1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review