Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| macrophage | 30 studies | 42% ± 24% | |
| myeloid cell | 7 studies | 28% ± 8% | |
| leukocyte | 3 studies | 24% ± 4% | |
| tissue-resident macrophage | 3 studies | 36% ± 14% | |
| microglial cell | 3 studies | 33% ± 17% |
Insufficient scRNA-seq data for expression of FOLR2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 95% | 1050.63 | 550 / 578 | 84% | 38.24 | 971 / 1155 |
| adrenal gland | 94% | 1208.50 | 242 / 258 | 79% | 37.95 | 181 / 230 |
| breast | 94% | 1170.92 | 430 / 459 | 76% | 23.94 | 853 / 1118 |
| bladder | 86% | 612.00 | 18 / 21 | 64% | 28.19 | 322 / 504 |
| intestine | 95% | 870.60 | 922 / 966 | 54% | 14.69 | 283 / 527 |
| thymus | 63% | 324.64 | 414 / 653 | 84% | 29.62 | 509 / 605 |
| kidney | 61% | 421.75 | 54 / 89 | 83% | 43.26 | 745 / 901 |
| ovary | 61% | 324.16 | 109 / 180 | 81% | 23.70 | 348 / 430 |
| skin | 48% | 253.57 | 866 / 1809 | 92% | 46.21 | 432 / 472 |
| brain | 34% | 118.68 | 911 / 2642 | 96% | 73.65 | 675 / 705 |
| stomach | 70% | 456.69 | 250 / 359 | 58% | 17.10 | 165 / 286 |
| liver | 39% | 206.10 | 88 / 226 | 80% | 28.24 | 323 / 406 |
| prostate | 51% | 204.34 | 124 / 245 | 65% | 11.67 | 328 / 502 |
| uterus | 58% | 291.19 | 99 / 170 | 56% | 22.28 | 256 / 459 |
| esophagus | 70% | 686.20 | 1006 / 1445 | 42% | 9.49 | 77 / 183 |
| pancreas | 18% | 49.59 | 59 / 328 | 81% | 34.41 | 145 / 178 |
| adipose | 99% | 2943.18 | 1191 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 97% | 115.03 | 28 / 29 |
| spleen | 94% | 1214.64 | 227 / 241 | 0% | 0 | 0 / 0 |
| blood vessel | 89% | 1010.64 | 1189 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 89% | 34.08 | 71 / 80 |
| heart | 77% | 543.37 | 666 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 62% | 14.50 | 28 / 45 |
| peripheral blood | 34% | 169.54 | 317 / 929 | 0% | 0 | 0 / 0 |
| muscle | 29% | 100.68 | 231 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0002548 | Biological process | monocyte chemotaxis |
| GO_0006954 | Biological process | inflammatory response |
| GO_0007155 | Biological process | cell adhesion |
| GO_0035036 | Biological process | sperm-egg recognition |
| GO_0007342 | Biological process | fusion of sperm to egg plasma membrane involved in single fertilization |
| GO_0071231 | Biological process | cellular response to folic acid |
| GO_0015884 | Biological process | folic acid transport |
| GO_0009986 | Cellular component | cell surface |
| GO_0009897 | Cellular component | external side of plasma membrane |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005542 | Molecular function | folic acid binding |
| GO_0038023 | Molecular function | signaling receptor activity |
| GO_0061714 | Molecular function | folic acid receptor activity |
| Gene name | FOLR2 |
| Protein name | FOLR2 protein Folate receptor beta (FR-beta) (Folate receptor 2) (Folate receptor, fetal/placental) (Placental folate-binding protein) (FBP) Folate receptor beta |
| Synonyms | |
| Description | FUNCTION: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. . |
| Accessions | ENST00000535625.5 ENST00000539412.5 F5H5L8 J3KR13 ENST00000536778.5 ENST00000454954.6 F5GXV3 A0AUM2 E7EU04 F5H3Z4 ENST00000298223.11 ENST00000538353.1 P14207 ENST00000321324.11 ENST00000541003.5 J3KQP4 ENST00000449475.6 F5GZ45 F5H4Z6 |
