Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| plasmacytoid dendritic cell | 16 studies | 30% ± 10% | |
| neutrophil | 7 studies | 27% ± 18% | |
| mast cell | 6 studies | 28% ± 18% | |
| monocyte | 3 studies | 26% ± 7% | |
| classical monocyte | 3 studies | 29% ± 5% | |
| myeloid cell | 3 studies | 17% ± 1% | |
| dendritic cell | 3 studies | 31% ± 5% | |
| megakaryocyte-erythroid progenitor cell | 3 studies | 33% ± 12% |
Insufficient scRNA-seq data for expression of CSF2RB at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 100% | 2809.44 | 578 / 578 | 92% | 17.86 | 1067 / 1155 |
| breast | 99% | 1348.91 | 455 / 459 | 87% | 12.64 | 978 / 1118 |
| esophagus | 90% | 655.96 | 1295 / 1445 | 85% | 10.23 | 155 / 183 |
| stomach | 82% | 578.48 | 295 / 359 | 81% | 14.10 | 231 / 286 |
| intestine | 88% | 1243.90 | 847 / 966 | 75% | 9.44 | 396 / 527 |
| bladder | 90% | 679.90 | 19 / 21 | 69% | 8.97 | 349 / 504 |
| thymus | 81% | 671.90 | 529 / 653 | 69% | 7.01 | 418 / 605 |
| skin | 68% | 514.46 | 1229 / 1809 | 67% | 9.99 | 318 / 472 |
| uterus | 65% | 338.56 | 111 / 170 | 63% | 7.86 | 289 / 459 |
| kidney | 48% | 259.89 | 43 / 89 | 72% | 8.22 | 647 / 901 |
| pancreas | 22% | 97.20 | 71 / 328 | 85% | 13.85 | 151 / 178 |
| prostate | 54% | 332.67 | 132 / 245 | 47% | 3.23 | 234 / 502 |
| adipose | 100% | 1685.92 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 98.23 | 29 / 29 |
| spleen | 100% | 5101.00 | 241 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 100% | 13276.81 | 928 / 929 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 87% | 34.33 | 39 / 45 |
| adrenal gland | 54% | 214.16 | 139 / 258 | 25% | 1.38 | 58 / 230 |
| blood vessel | 70% | 586.91 | 939 / 1335 | 0% | 0 | 0 / 0 |
| ovary | 13% | 60.93 | 24 / 180 | 45% | 3.23 | 193 / 430 |
| liver | 24% | 106.40 | 55 / 226 | 26% | 2.18 | 107 / 406 |
| brain | 11% | 48.76 | 297 / 2642 | 38% | 2.62 | 270 / 705 |
| heart | 37% | 183.31 | 317 / 861 | 0% | 0 | 0 / 0 |
| muscle | 12% | 59.93 | 99 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 6% | 0.31 | 5 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0019221 | Biological process | cytokine-mediated signaling pathway |
| GO_0038156 | Biological process | interleukin-3-mediated signaling pathway |
| GO_0036016 | Biological process | cellular response to interleukin-3 |
| GO_0038043 | Biological process | interleukin-5-mediated signaling pathway |
| GO_0007165 | Biological process | signal transduction |
| GO_0016064 | Biological process | immunoglobulin mediated immune response |
| GO_0038157 | Biological process | granulocyte-macrophage colony-stimulating factor signaling pathway |
| GO_0007259 | Biological process | cell surface receptor signaling pathway via JAK-STAT |
| GO_0070665 | Biological process | positive regulation of leukocyte proliferation |
| GO_0032496 | Biological process | response to lipopolysaccharide |
| GO_0007585 | Biological process | respiratory gaseous exchange by respiratory system |
| GO_0009897 | Cellular component | external side of plasma membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0030526 | Cellular component | granulocyte macrophage colony-stimulating factor receptor complex |
| GO_0015026 | Molecular function | coreceptor activity |
| GO_0038023 | Molecular function | signaling receptor activity |
| GO_0004912 | Molecular function | interleukin-3 receptor activity |
| GO_0004914 | Molecular function | interleukin-5 receptor activity |
| GO_0004896 | Molecular function | cytokine receptor activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | CSF2RB |
| Protein name | Alternative protein CSF2RB CSF2RB protein Cytokine receptor common subunit beta (CDw131) (GM-CSF/IL-3/IL-5 receptor common beta subunit) (CD antigen CD131) Colony stimulating factor 2 receptor subunit beta |
| Synonyms | IL5RB IL3RB |
| Description | FUNCTION: Cell surface receptor that plays a role in immune response and controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Acts by forming an heterodimeric receptor through interaction with different partners such as IL3RA, IL5RA or CSF2RA . In turn, participates in various signaling pathways including interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor/CSF2 pathways. In unstimulated conditions, interacts constitutively with JAK1 and ligand binding leads to JAK1 stimulation and subsequent activation of the JAK-STAT pathway . . |
| Accessions | L0R5A1 B0QY07 ENST00000406230.5 [P32927-2] P32927 ENST00000421539.1 ENST00000403662.8 [P32927-1] L8EC56 Q6NSJ8 |
